HAMAP rule MF_01813
General rule information
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| Accession | MF_01813 |
| Dates | 6-OCT-2003 (Created)
2-FEB-2024 (Last updated, Version 35) |
| Name | MenG_UbiE_methyltr |
| Scope(s) |
Bacteria Archaea |
| Template(s) | P31113 (MENG_BACSU); P0A887 (UBIE_ECOLI); P49017 (COQ5_YEAST); [ Recover all ] |
| Triggered by |
case c? <OC:Bacteria> or <OC:Archaea>
HAMAP; MF_01813 (Get profile general information and statistics) end case
|
Propagated annotation
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Identifier, protein and gene names
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| case <OC:Pseudomonadota> | |
| Identifier | UBIE |
| Protein name | RecName: Full=Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE; EC=2.1.1.163; EC=2.1.1.201; AltName: Full=2-methoxy-6-polyprenyl-1,4-benzoquinol methylase; AltName: Full=Demethylmenaquinone methyltransferase; |
| Gene name | Name=ubiE; |
| else | |
| Identifier | MENG |
| Protein name | RecName: Full=Demethylmenaquinone methyltransferase; EC=2.1.1.163; |
| Gene name | Name=menG; |
| end case | |
Comments
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| case <OC:Pseudomonadota> | |
| FUNCTION | Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2). |
| CATALYTIC ACTIVITY | Reaction=a 2-demethylmenaquinol + S-adenosyl-L-methionine = a menaquinol + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:42640, Rhea:RHEA-COMP:9539, Rhea:RHEA-COMP:9563, ChEBI:CHEBI:15378, ChEBI:CHEBI:18151, ChEBI:CHEBI:55437, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789; EC=2.1.1.163; |
| CATALYTIC ACTIVITY | Reaction=a 2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol + S- adenosyl-L-methionine = a 6-methoxy-3-methyl-2-all-trans-polyprenyl- 1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:28286, Rhea:RHEA-COMP:10858, Rhea:RHEA-COMP:10859, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:84166, ChEBI:CHEBI:84167; EC=2.1.1.201; |
| PATHWAY | Quinol/quinone metabolism; menaquinone biosynthesis; menaquinol from 1,4-dihydroxy-2-naphthoate: step 2/2. |
| PATHWAY | Cofactor biosynthesis; ubiquinone biosynthesis. |
| else | |
| FUNCTION | Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2). |
| CATALYTIC ACTIVITY | Reaction=a 2-demethylmenaquinol + S-adenosyl-L-methionine = a menaquinol + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:42640, Rhea:RHEA-COMP:9539, Rhea:RHEA-COMP:9563, ChEBI:CHEBI:15378, ChEBI:CHEBI:18151, ChEBI:CHEBI:55437, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789; EC=2.1.1.163; |
| PATHWAY | Quinol/quinone metabolism; menaquinone biosynthesis; menaquinol from 1,4-dihydroxy-2-naphthoate: step 2/2. |
| end case | |
| SIMILARITY | Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family. |
Keywords
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| Menaquinone biosynthesis | |
| case <OC:Pseudomonadota> | |
| Ubiquinone biosynthesis | |
| end case | |
| S-adenosyl-L-methionine | |
| Transferase | |
| Methyltransferase | |
Gene Ontology
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| case <OCellular component:Pseudomonadota> | |
| GO:0008425; Molecular function:2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity | |
| GO:0006744; Biological process:ubiquinone biosynthetic process | |
| GO:0009060; Biological process:aerobic respiration | |
| end case | |
| GO:0043770; Molecular function:demethylmenaquinone methyltransferase activity | |
| GO:0009234; Biological process:menaquinone biosynthetic process | |
Cross-references
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| Pfam | PF01209; Ubie_methyltran; 1; |
| NCBIfam | TIGR01934; MenG_MenH_UbiE; 1; |
| PROSITE | PS51608; SAM_MT_UBIE; 1; |
| PROSITE | PS01183; UBIE_1; 1; |
| PROSITE | PS01184; UBIE_2; 1; |
Features
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| From: COQ5_YEAST (P49017) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 179 | 180 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
[ND]-x | ||||||||
| BINDING | 122 | 122 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
[ST] | ||||||||
| BINDING | 148 | 148 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
D | ||||||||
| BINDING | 197 | 197 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
S | ||||||||
Additional information
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| Size range | 220-352 amino acids |
| Related rules |
MF_03192 MF_01982 |
| Fusion | Nter: None Cter: None |