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HAMAP annotation rule: MF_01813
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General rule information

Accession MF_01813
Dates 6-OCT-2003 (Created)
2-DEC-2011 (Last updated, Version 19)
Data class Protein
Predictors HAMAP; MF_01813; [distribution of match scores in UniProtKB];[seed alignment for MF_01813]
Names UbiE_methyltran


Propagated annotation

Identifier, protein and gene names
Identifier UBIE

case <OC:Proteobacteria>
Protein name
RecName: Full=Ubiquinone/menaquinone biosynthesis methyltransferase ubiE;
EC=2.1.1.163;
EC=2.1.1.201;
AltName: Full=2-methoxy-6-polyprenyl-1,4-benzoquinol methylase;
AltName: Full=Demethylmenaquinone methyltransferase;
end case


case not <OC:Proteobacteria>
Protein name
RecName: Full=Demethylmenaquinone methyltransferase;
EC=2.1.1.163;
AltName: Full=Menaquinone biosynthesis methyltransferase ubiE;
end case

Gene name ubiE
Comments

case <OC:Proteobacteria>
FUNCTION: Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity).
CATALYTIC ACTIVITY: A demethylmenaquinone + S-adenosyl-L-methionine = a menaquinol + S-adenosyl-L-homocysteine.
CATALYTIC ACTIVITY: S-adenosyl-L-methionine + 2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol = S-adenosyl-L-homocysteine + 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol.
PATHWAY: Cofactor biosynthesis; menaquinone biosynthesis; menaquinone-2 from chorismate: step 8/8.
PATHWAY: Cofactor biosynthesis; ubiquinone biosynthesis.
end case


case not <OC:Proteobacteria>
FUNCTION: Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity).
CATALYTIC ACTIVITY: A demethylmenaquinone + S-adenosyl-L-methionine = a menaquinol + S-adenosyl-L-homocysteine.
PATHWAY: Cofactor biosynthesis; menaquinone biosynthesis; menaquinone-2 from chorismate: step 8/8.
end case

SIMILARITY: Belongs to the methyltransferase superfamily. UbiE family.
Cross-references
Pfam PF01209; Ubie_methyltran; 1;
PROSITE PS01183; UBIE_1; 1;
PS01184; UBIE_2; 1;
Keywords
Menaquinone biosynthesis.

case <OC:Proteobacteria>
Ubiquinone biosynthesis.
end case

Transferase, Methyltransferase.
Gene Ontology

case <OC:Proteobacteria>
GO:0008425; Molecular function: 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity.
GO:0009060; Biological process: aerobic respiration.
end case



Additional information

Size range: 225-291 amino acids
Related UniRules: None
Template: O86169 (UBIE_GEOSE); P31113 (UBIE_BACSU); P0A887 (UBIE_ECOLI): [Recover all]
Scope: Bacteria
Fusion: Nter: None; Cter: None
Duplicate: None
Plasmid encoded: None

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UniProtKB rule member sequences