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HAMAP rule MF_01813

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General rule information [?]

Accession MF_01813
Dates 6-OCT-2003 (Created)
1-JUN-2023 (Last updated, Version 34)
Name MenG_UbiE_methyltr
Scope(s) Bacteria
Archaea
Template(s) P31113 (MENG_BACSU); P0A887 (UBIE_ECOLI); P49017 (COQ5_YEAST); [ Recover all ]
Triggered by
case c? <OC:Bacteria> or <OC:Archaea>
HAMAP; MF_01813 (Get profile general information and statistics)
end case

Propagated annotation [?]

Identifier, protein and gene names [?]

case <OC:Pseudomonadota>
Identifier UBIE
Protein name RecName: Full=Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE;
                 EC=2.1.1.163;
                 EC=2.1.1.201;
AltName: Full=2-methoxy-6-polyprenyl-1,4-benzoquinol methylase;
AltName: Full=Demethylmenaquinone methyltransferase;
Gene name Name=ubiE;
else
Identifier MENG
Protein name RecName: Full=Demethylmenaquinone methyltransferase;
                 EC=2.1.1.163;
Gene name Name=menG;
end case

Comments [?]

case <OC:Pseudomonadota>
FUNCTIONMethyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2).
CATALYTIC ACTIVITY Reaction=a 2-demethylmenaquinol + S-adenosyl-L-methionine = a menaquinol + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:42640, Rhea:RHEA-COMP:9539, Rhea:RHEA-COMP:9563, ChEBI:CHEBI:15378, ChEBI:CHEBI:18151, ChEBI:CHEBI:55437, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789; EC=2.1.1.163;
CATALYTIC ACTIVITY Reaction=a 2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol + S- adenosyl-L-methionine = a 6-methoxy-3-methyl-2-all-trans-polyprenyl- 1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:28286, Rhea:RHEA-COMP:10858, Rhea:RHEA-COMP:10859, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:84166, ChEBI:CHEBI:84167; EC=2.1.1.201;
PATHWAYQuinol/quinone metabolism; menaquinone biosynthesis; menaquinol from 1,4-dihydroxy-2-naphthoate: step 2/2.
PATHWAYCofactor biosynthesis; ubiquinone biosynthesis.
else
FUNCTIONMethyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).
CATALYTIC ACTIVITY Reaction=a 2-demethylmenaquinol + S-adenosyl-L-methionine = a menaquinol + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:42640, Rhea:RHEA-COMP:9539, Rhea:RHEA-COMP:9563, ChEBI:CHEBI:15378, ChEBI:CHEBI:18151, ChEBI:CHEBI:55437, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789; EC=2.1.1.163;
PATHWAYQuinol/quinone metabolism; menaquinone biosynthesis; menaquinol from 1,4-dihydroxy-2-naphthoate: step 2/2.
end case
SIMILARITYBelongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.

Keywords [?]


Gene Ontology [?]

case <OCellular component:Pseudomonadota>
GO:0008425; Molecular function:2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity
GO:0009060; Biological process:aerobic respiration
end case
GO:0009234; Biological process:menaquinone biosynthetic process

Cross-references [?]

Pfam PF01209; Ubie_methyltran; 1;
NCBIfam TIGR01934; MenG_MenH_UbiE; 1;
PROSITE PS51608; SAM_MT_UBIE; 1;
PROSITE PS01183; UBIE_1; 1;
PROSITE PS01184; UBIE_2; 1;

Features [?]

From: COQ5_YEAST (P49017)
Key From To Description Tag Condition FTGroup
BINDING 179 180 /ligand="S-adenosyl-L-methionine"
/ligand_id="ChEBI:CHEBI:59789"
[ND]-x
BINDING 122 122 /ligand="S-adenosyl-L-methionine"
/ligand_id="ChEBI:CHEBI:59789"
[ST]
BINDING 148 148 /ligand="S-adenosyl-L-methionine"
/ligand_id="ChEBI:CHEBI:59789"
D
BINDING 197 197 /ligand="S-adenosyl-L-methionine"
/ligand_id="ChEBI:CHEBI:59789"
S

Additional information [?]

Size range 220-352 amino acids
Related rules MF_03192
MF_01982
Fusion Nter: None Cter: None



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