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HAMAP annotation rule: MF_01815
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General rule information

Accession MF_01815
Dates 30-JUL-2003 (Created)
7-OCT-2011 (Last updated, Version 32)
Data class Protein
Predictors HAMAP; MF_01815; [distribution of match scores in UniProtKB];[seed alignment for MF_01815]
Names FabH


Propagated annotation

Identifier, protein and gene names
Identifier FABH
Protein name
RecName: Full=3-oxoacyl-[acyl-carrier-protein] synthase 3;
EC=2.3.1.180;
AltName: Full=3-oxoacyl-[acyl-carrier-protein] synthase III;
AltName: Full=Beta-ketoacyl-ACP synthase III;
Short=KAS III;
Gene name fabH
Comments
FUNCTION: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids (By similarity).
CATALYTIC ACTIVITY: Acetyl-CoA + malonyl-[acyl-carrier-protein] = acetoacetyl-[acyl-carrier-protein] + CoA + CO(2).
PATHWAY: Lipid metabolism; fatty acid biosynthesis.
SUBUNIT: Homodimer (By similarity).

case <OG:Chloroplast>
SUBCELLULAR LOCATION: Plastid, chloroplast.
end case


case not <OG:Chloroplast>
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
end case

DOMAIN: The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH (By similarity).
SIMILARITY: Belongs to the FabH family.
Cross-references
TIGRFAMs TIGR00747; FabH; 1;
Keywords

case not <OG:Chloroplast>
Cytoplasm.
end case

Lipid synthesis, Fatty acid biosynthesis, Transferase, Acyltransferase, Multifunctional enzyme.
Gene Ontology
GO:0004315; Molecular function: 3-oxoacyl-[acyl-carrier-protein] synthase activity.
GO:0006633; Biological process: fatty acid biosynthetic process.

case <OG:Chloroplast>
GO:0009507; Cellular component: chloroplast.
end case


case not <OG:Chloroplast>
GO:0005737; Cellular component: cytoplasm.
end case

Features
From: FABH_ECOLI (P0A6R0)
Key     From     To       Description   Condition   FTGroup
ACT_SITE     112     112       By similarity   C  
ACT_SITE     244     244       By similarity   H  
ACT_SITE     274     274       By similarity   N  
REGION     245     249       ACP-binding (By similarity)   [QS]-[AP]-N-x-R  


Additional information

Size range: 309-364 amino acids
Related UniRules: None
Template: P0A6R0 (FABH_ECOLI); P0A574 (FABH_MYCTU); P68795 (FABH_STAAM); Q9F6D4 (FABH_STRLI): [Recover all]
Scope: Bacteria
Plastid
Fusion: Nter: None; Cter: None
Duplicate: in BACAN, BACHD, BACSU, BACTN, DEIRA, LACPL, STAES, STRAW, STRCO, VIBCH, VIBPA, VIBVU
Plasmid encoded: in STAES, STRCO

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UniProtKB rule member sequences