HAMAP

Accession	MF_01816
Dates	17-AUG-2003 (Created) 25-NOV-2009 (Last updated, Version 18)

Data class

Protein

Predictors

HAMAP; MF_01816; [distribution of match scores in UniProtKB];[seed alignment for MF_01816]

Names

Recomb_XerS

Identifier

XERS

Protein name

RecName: Full=Tyrosine recombinase xerS;

Gene name

xerS

FUNCTION: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division (By similarity).

ENZYME REGULATION: FtsK is required for efficient recombination (By similarity).

SUBUNIT: May form a cyclic homotetramer complex (By similarity).

SUBCELLULAR LOCATION: Cytoplasm (By similarity).

SIMILARITY: Belongs to the 'phage' integrase family. XerS subfamily.

Pfam	PF00589; Phage_integrase; 1; PF02899; Phage_integr_N; 1;

Cell cycle, Cell division, Chromosome partition, Cytoplasm, DNA integration, DNA recombination, DNA-binding.

GO:0009037; Molecular function: tyrosine-based site-specific recombinase activity.
GO:0007059; Biological process: chromosome segregation.
GO:0006310; Biological process: DNA recombination.
GO:0006313; Biological process: transposition, DNA-mediated.
GO:0005737; Cellular component: cytoplasm.

From: XERS_STRA3 (P67632)
Key		From		To		Description		Condition		FTGroup
ACT_SITE		210		210		By similarity		R
ACT_SITE		234		234		By similarity		K
ACT_SITE		306		306		By similarity		H
ACT_SITE		309		309		By similarity		R
ACT_SITE		332		332		By similarity		H
ACT_SITE		341		341		O-(3'-phospho-DNA)-tyrosine intermediate (By similarity)		Y

Size range:	350-360 amino acids
Related UniRules:	MF_01807 (XERD); MF_01808 (XERC); MF_01817 (XERDL)
Template:	Q7ZAK7 (XERS_STRR6); P0A8P6 (XERC_ECOLI); P44818 (XERC_HAEIN); Q51566 (XERC_PSEAE): [Recover all]
Scope:	Bacteria; Streptococcaceae
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None
Comments:	XerC and xerD proteins from Streptococcaceae are different compared to other bacterias. If xerC contains all the conserved active sites, the rest of the sequence differs from other xerC proteins.