HAMAP

Accession	MF_01817
Dates	17-AUG-2003 (Created) 25-NOV-2009 (Last updated, Version 19)

Data class

Protein

Predictors

HAMAP; MF_01817; [distribution of match scores in UniProtKB];[seed alignment for MF_01817]

Names

Recomb_XerD_like

Identifier

XERDL

Protein name

RecName: Full=Tyrosine recombinase xerD-like;

FUNCTION: Putative tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity).

SUBCELLULAR LOCATION: Cytoplasm (By similarity).

SIMILARITY: Belongs to the 'phage' integrase family. XerD-like subfamily.

Pfam	PF00589; Phage_integrase; 1; PF02899; Phage_integr_N; 1;

Cytoplasm, DNA recombination, DNA integration, DNA-binding.

GO:0009037; Molecular function: tyrosine-based site-specific recombinase activity.
GO:0006310; Biological process: DNA recombination.
GO:0006313; Biological process: transposition, DNA-mediated.
GO:0005737; Cellular component: cytoplasm.

From: XERDL_LACLA (Q9CG32)
Key		From		To		Description		Condition		FTGroup
ACT_SITE		236		236		O-(3'-phospho-DNA)-tyrosine intermediate (By similarity)		Y

Size range:	238-253 amino acids
Related UniRules:	MF_01807 (XERD); MF_01808 (XERC); MF_01816 (XERS)
Template:	P0A4T0 (XERDL_STRR6); Q9CG32 (XERDL_LACLA): [Recover all]
Scope:	Bacteria; Streptococcaceae
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None
Comments:	Although strongly related to xerD, it constitutes a distinct protein family. In contrast to the classic xerD protein, it does not contain the Arg-His-Arg-His (R-H-R-H) sandwich residues that are clustered with the Tyr active site. It also lacks the C-terminal region which is known to mediate the interaction with xerC. It is therefore unknown whether it has tyrosine recombinase activity or acts as a regulator.