HAMAP

Accession	MF_01821
Dates	12-DEC-2003 (Created) 2-DEC-2011 (Last updated, Version 17)

Data class

Protein

Predictors

HAMAP; MF_01821; [distribution of match scores in UniProtKB];[seed alignment for MF_01821]

Names

Helicase_RapA

Identifier

RAPA

Protein name

RecName: Full=RNA polymerase-associated protein rapA; EC=3.6.4.-; AltName: Full=ATP-dependent helicase hepA;

Gene name

rapA

FUNCTION: Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity).

SUBUNIT: Interacts with the RNAP. Has a higher affinity for the core RNAP than for the holoenzyme. Its ATPase activity is stimulated by binding to RNAP (By similarity).

SIMILARITY: Belongs to the SNF2/RAD54 helicase family. RapA subfamily.

SIMILARITY: Contains 1 helicase ATP-binding domain.

SIMILARITY: Contains 1 helicase C-terminal domain.

Pfam	PF00271; Helicase_C; 1; PF00176; SNF2_N; 1;
PROSITE	PS00690; DEAH_ATP_HELICASE; 1; PS51192; HELICASE_ATP_BIND_1; 1; trigger=PRU00541; PS51194; HELICASE_CTER; 1; trigger=PRU00542;

Transcription, Transcription regulation, Hydrolase, Helicase, Activator, ATP-binding, Nucleotide-binding, DNA-binding.

GO:0004386; Molecular function: helicase activity.
GO:0005524; Molecular function: ATP binding.
GO:0006355; Biological process: regulation of transcription, DNA-dependent.

From: RAPA_ECOLI (P60240)
Key		From		To		Description		Condition		FTGroup
NP_BIND		177		184		ATP (By similarity)		D-x-x-G-x-G-K-T
MOTIF		280		283		DEAH box		D-E-[ALIV]-H

Size range:	556-1170 amino acids
Related UniRules:	None
Template:	P60240 (RAPA_ECOLI)
Scope:	Bacteria; Gammaproteobacteria
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None