HAMAP

Accession	MF_01839
Dates	28-JUL-2005 (Created) 15-SEP-2011 (Last updated, Version 13)

Data class

Protein

Predictors

HAMAP; MF_01839; [distribution of match scores in UniProtKB];[seed alignment for MF_01839]

Names

NO_factor_SlmA

Identifier

SLMA

Protein name

RecName: Full=Nucleoid occlusion factor SlmA;

Gene name

slmA

FUNCTION: Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity).

SUBUNIT: Homodimer (By similarity). Interacts with FtsZ (By similarity).

SUBCELLULAR LOCATION: Cytoplasm, nucleoid (By similarity).

SIMILARITY: Belongs to the nucleoid occlusion factor SlmA family.

PROSITE	PS01081; HTH_TETR_1; 1; PS50977; HTH_TETR_2; 1; trigger=PRU00335;
Pfam	PF00440; TetR_N; 1;
General	Coiled_coil; -; 0-1; trigger=Yes;

Cell cycle, Cell division, Cytoplasm, DNA-binding.

GO:0005737; Cellular component: cytoplasm.
GO:0043590; Cellular component: bacterial nucleoid.
GO:0032188; Biological process: establishment of contractile ring localization involved in cell cycle cytokinesis.
GO:0043565; Molecular function: sequence-specific DNA binding.
GO:0005515; Molecular function: protein binding.

Size range:	195-218 amino acids
Related UniRules:	None
Template:	P0C093 (SLMA_ECOLI)
Scope:	Bacteria; Gammaproteobacteria
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None
Comments:	Although SlmA is a member of the TetR family, it does not exert its function via transcription regulation (PubMed:21113127).