HAMAP

Accession	MF_01842
Dates	15-DEC-2005 (Created) 25-NOV-2009 (Last updated, Version 7)

Data class

Protein

Predictors

HAMAP; MF_01842; [distribution of match scores in UniProtKB];[seed alignment for MF_01842]

Names

Archaemetzincin

Identifier

AMZA

Protein name

RecName: Full=Archaemetzincin; EC=3.-.-.-;

Gene name

amzA

FUNCTION: Probable zinc metalloprotease (By similarity).

SIMILARITY: Belongs to the peptidase archaemetzincin family.

PROSITE	PS00142; ZINC_PROTEASE; 1;
Pfam	PF07998; Peptidase_M54; 1;
PIRSF	PIRSF005785; Zn-prot_arch; 1;

Hydrolase, Metal-binding, Metalloprotease, Protease, Zinc.

GO:0008237; Molecular function: metallopeptidase activity.
GO:0006508; Biological process: proteolysis.
GO:0008270; Molecular function: zinc ion binding.

From: AMZA_AERPE (Q9YFV3)
Key		From		To		Description		Condition		FTGroup
ACT_SITE		133		133		By similarity		E
METAL		132		132		Zinc; catalytic (By similarity)		H
METAL		136		136		Zinc; catalytic (By similarity)		H
METAL		143		143		Zinc; catalytic (Potential)		C

Size range:	155-192 amino acids
Related UniRules:	None
Template:	Q400G9 (AMZ1_HUMAN)
Scope:	Archaea
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None
Comments:	Although it has not been proved in prokaryotes, its function as metalloprotease is probable due to the strong similarities with the AMZ1 and AMZ2 enzymes. See: RX PubMed=15972818; DOI=10.1074/jbc.M504533200; RA Diaz-Perales A., Quesada V., Peinado J.R., Ugalde A.P., Alvarez J., RA Suarez M.F., Gomis-Rueth X., Lopez-Otin C.; RT "Identification and characterization of human archaemetzincin-1 and - RT 2, two novel members of a family of metalloproteases widely RT distributed in archae."; RL J. BiolQ400G9. Chem. 280:30367-30375(2005). The family has been identified in Archaea and described in: RX PubMed=12746556; RA Gomis-Rueth F.X.; RT "Structural aspects of the metzincin clan of metalloendopeptidases."; RL Mol. Biotechnol. 24:157-202(2003).