HAMAP rule MF_01844
General rule information
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| Accession | MF_01844 |
| Dates | 22-APR-2008 (Created)
1-JUN-2023 (Last updated, Version 26) |
| Name | NhaA |
| Scope(s) |
Bacteria |
| Template(s) | P13738 (NHAA_ECOLI); O85187 (NHAA_VIBCH); Q56725 (NHAA_VIBPA); [ Recover all ] |
| Triggered by |
HAMAP; MF_01844 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | NHAA |
| Protein name | RecName: Full=Na(+)/H(+) antiporter NhaA; AltName: Full=Sodium/proton antiporter NhaA; |
| Gene name | Name=nhaA; |
Comments
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| FUNCTION | Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons. |
| CATALYTIC ACTIVITY | Reaction=2 H(+)(out) + Na(+)(in) = 2 H(+)(in) + Na(+)(out); Xref=Rhea:RHEA:29251, ChEBI:CHEBI:15378, ChEBI:CHEBI:29101; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:29252; |
| case not defined <Property:Membrane> or <Property:Membrane=1> | |
| SUBCELLULAR LOCATION | Cell membrane; Multi-pass membrane protein. |
| else case <Property:Membrane=2> | |
| SUBCELLULAR LOCATION | Cell inner membrane; Multi-pass membrane protein. |
| end case | |
| SIMILARITY | Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family. |
Keywords
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| Antiport | |
| Cell membrane | |
| case defined <Property:Membrane> and <Property:Membrane=2> | |
| Cell inner membrane | |
| end case | |
| Ion transport | |
| Membrane | |
| Sodium | |
| Sodium transport | |
| Transmembrane | |
| Transport | |
| Transmembrane helix | |
Gene Ontology
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| GO:0015297; Molecular function:antiporter activity |
| GO:0015081; Molecular function:sodium ion transmembrane transporter activity |
| GO:0006814; Biological process:sodium ion transport |
| GO:0005886; Cellular component:plasma membrane |
Cross-references
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| Pfam | PF06965; Na_H_antiport_1; 1; |
| NCBIfam | TIGR00773; NhaA; 1; |
| General | Transmembrane; -; 9-12; |
Features
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| From: NHAA_ECOLI (P13738) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| case <OC:Escherichia> or <OC:Shigella> | ||||||||||||
| TOPO_DOM | Nter | 11 | /note="Cytoplasmic" | |||||||||
| TRANSMEM | 12 | 31 | /note="Helical; Name=1" | |||||||||
| TOPO_DOM | 32 | 58 | /note="Periplasmic" | |||||||||
| TRANSMEM | 59 | 80 | /note="Helical; Name=2" | |||||||||
| TOPO_DOM | 81 | 96 | /note="Cytoplasmic" | |||||||||
| TRANSMEM | 97 | 116 | /note="Helical; Name=3" | |||||||||
| TOPO_DOM | 117 | 122 | /note="Periplasmic" | |||||||||
| TRANSMEM | 123 | 130 | /note="Helical; Name=4" | |||||||||
| TOPO_DOM | 131 | 154 | /note="Cytoplasmic" | |||||||||
| TRANSMEM | 155 | 176 | /note="Helical; Name=5" | |||||||||
| TOPO_DOM | 177 | 180 | /note="Periplasmic" | |||||||||
| TRANSMEM | 181 | 200 | /note="Helical; Name=6" | |||||||||
| TOPO_DOM | 201 | 204 | /note="Cytoplasmic" | |||||||||
| TRANSMEM | 205 | 222 | /note="Helical; Name=7" | |||||||||
| TOPO_DOM | 223 | 223 | /note="Periplasmic" | |||||||||
| TRANSMEM | 224 | 236 | /note="Helical; Name=8" | |||||||||
| TOPO_DOM | 237 | 253 | /note="Cytoplasmic" | |||||||||
| TRANSMEM | 254 | 272 | /note="Helical; Name=9" | |||||||||
| TOPO_DOM | 273 | 286 | /note="Periplasmic" | |||||||||
| TRANSMEM | 287 | 310 | /note="Helical; Name=10" | |||||||||
| TOPO_DOM | 311 | 339 | /note="Cytoplasmic" | |||||||||
| TRANSMEM | 340 | 350 | /note="Helical; Name=11" | |||||||||
| TOPO_DOM | 351 | 357 | /note="Periplasmic" | |||||||||
| TRANSMEM | 358 | 380 | /note="Helical; Name=12" | |||||||||
| TOPO_DOM | 381 | Cter | /note="Cytoplasmic" | |||||||||
| end case | ||||||||||||
Additional information
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| Size range | 376-503 amino acids |
| Related rules |
None |
| Fusion | Nter: <Unknown>; <Thioredoxin domain> Cter: <Thioredoxin domain>; <Peptidase S49> |
| Comments | Some of the Rickettsiales are shorter than orthologs; sequences are not shown in alignment and not taken into account in size range. |