HAMAP

Accession	MF_01844
Dates	22-APR-2008 (Created) 16-JUL-2010 (Last updated, Version 16)

Data class

Protein

Predictors

HAMAP; MF_01844; [distribution of match scores in UniProtKB];[seed alignment for MF_01844]

Names

NhaA

Identifier

NHAA

Protein name

RecName: Full=Na(+)/H(+) antiporter nhaA; AltName: Full=Sodium/proton antiporter nhaA;

Gene name

nhaA

FUNCTION: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons (By similarity).

SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (By similarity).

SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein (By similarity).

SIMILARITY: Belongs to the nhaA Na(+)/H(+) (TC 2.A.33) antiporter family.

Pfam	PF06965; Na_H_antiport_1; 1;
TIGRFAMs	TIGR00773; NhaA; 1;

General

Transmembrane; -; 9-12; trigger=Yes;

Antiport, Cell membrane.

Cell inner membrane.

Ion transport, Membrane, Sodium, Sodium transport, Transmembrane, Transport, Transmembrane helix.

GO:0015297; Molecular function: antiporter activity.
GO:0015081; Molecular function: sodium ion transmembrane transporter activity.
GO:0006814; Biological process: sodium ion transport.
GO:0005886; Cellular component: plasma membrane.

From: NHAA_ECOLI (P13738)
Key		From		To		Description		Condition		FTGroup
TOPO_DOM		Nter		11		Cytoplasmic (By similarity)
TRANSMEM		12		30		Helical; (By similarity)
TOPO_DOM		31		58		Periplasmic (By similarity)
TRANSMEM		59		85		Helical; (By similarity)
TOPO_DOM		86		94		Cytoplasmic (By similarity)
TRANSMEM		95		116		Helical; (By similarity)
TOPO_DOM		117		120		Periplasmic (By similarity)
TRANSMEM		121		143		Helical; (By similarity)
TOPO_DOM		144		149		Cytoplasmic (By similarity)
TRANSMEM		150		175		Helical; (By similarity)
TOPO_DOM		176		181		Periplasmic (By similarity)
TRANSMEM		182		200		Helical; (By similarity)
TOPO_DOM		201		204		Cytoplasmic (By similarity)
TRANSMEM		205		218		Helical; (By similarity)
TOPO_DOM		219		222		Periplasmic (By similarity)
TRANSMEM		223		236		Helical; (By similarity)
TOPO_DOM		237		246		Cytoplasmic (By similarity)
TRANSMEM		247		271		Helical; (By similarity)
TOPO_DOM		272		289		Periplasmic (By similarity)
TRANSMEM		290		311		Helical; (By similarity)
TOPO_DOM		312		326		Cytoplasmic (By similarity)
TRANSMEM		327		350		Helical; (By similarity)
TOPO_DOM		351		356		Periplasmic (By similarity)
TRANSMEM		357		382		Helical; (By similarity)
TOPO_DOM		383		Cter		Cytoplasmic (By similarity)

Size range:	376-503 amino acids
Related UniRules:	None
Template:	P13738 (NHAA_ECOLI); O85187 (NHAA_VIBCH); Q56725 (NHAA_VIBPA): [Recover all]
Scope:	Bacteria
Fusion:	Nter: <Unknown>, <Thioredoxin domain>; Cter: <Thioredoxin domain>, <Peptidase S49>
Duplicate:	in ACICJ, ARCB4, CAMFF, CAMHC, CAMJ8, CAMJD, CAMJE, CAMJJ, CAMJR, CLAM3, CLOB8, DEIGD, ERYLH, FLAJ1, FRAAA, HELHP, KINRD, KLEP7, MAGSM, MYCGI, MYCSJ, MYCSK, MYCSS, MYCVP, MYXXD, NOCSJ, NOVAD, OCHA4, PELCD, PELPD, PSE14, PSEA6, PSEP1, PSEPK, PSESM, PSEU2, PSYIN, RHOSR, SACD2, SACEN, SALAI, SALTO, SHEDO, SORC5, STRCO, VIBVU
Plasmid encoded:	in ACICJ, DEIGD, KLEP7, NITHX, RHIME
Comments:	Some of the Rickettsiales are shorter than orthologs; sequences are not shown in alignment and not taken into account in size range.