HAMAP

Accession	MF_01847
Dates	4-JUN-2008 (Created) 25-NOV-2009 (Last updated, Version 4)

Data class

Protein

Predictors

HAMAP; MF_01847; [distribution of match scores in UniProtKB];[seed alignment for MF_01847]

Names

HMP-PP_phosphat

Identifier

COF

Protein name

RecName: Full=HMP-PP phosphatase; EC=3.6.1.-;

Gene name

cof

FUNCTION: Catalyzes the hydrolysis of 4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5-hydroxymethylpyrimidine phosphate (HMP-P) (By similarity).

SIMILARITY: Belongs to the HAD-like hydrolase superfamily. Cof family.

PROSITE	PS01228; COF_1; 1; PS01229; COF_2; 1;
Pfam	PF00702; Hydrolase; 1; PF08282; Hydrolase_3; 1;
TIGRFAMs	TIGR00099; Cof-subfamily; 1; TIGR01484; HAD-SF-IIB; 1;

Hydrolase.

GO:0016818; Molecular function: hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides.

Size range:	260-274 amino acids
Related UniRules:	None
Template:	P46891 (COF_ECOLI)
Scope:	Bacteria; Enterobacteriaceae
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None
Comments:	The N-terminus of ECOLC is shorter. SHIDS is truncated and probably not functional. These sequences have not been included in the alignment.