HAMAP

Accession	MF_01870
Dates	3-AUG-2009 (Created) 19-OCT-2010 (Last updated, Version 7)

Data class

Protein

Predictors

HAMAP; MF_01870; [distribution of match scores in UniProtKB];[seed alignment for MF_01870]

Names

ArnD

Identifier

ARND

Protein name

RecName: Full=Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; EC=3.5.1.n3;

Gene name

arnD

FUNCTION: Catalyzes the deformylation of 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity).

CATALYTIC ACTIVITY: 4-deoxy-4-formamido-beta-L-arabinose di-trans,poly-cis-undecaprenyl phosphate + H(2)O = 4-amino-4-deoxy-alpha-L-arabinose di-trans,poly-cis-undecaprenyl phosphate + formate.

PATHWAY: Glycolipid biosynthesis; 4-amino-4-deoxy-alpha-L-arabinose undecaprenyl phosphate biosynthesis; 4-amino-4-deoxy-alpha-L-arabinose undecaprenyl phosphate from UDP-4-deoxy-4-formamido-beta-L-arabinose and undecaprenyl phosphate: step 2/2.

PATHWAY: Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis.

SIMILARITY: Belongs to the polysaccharide deacetylase family. ArnD deformylase subfamily.

Pfam	PF01522; Polysacc_deac_1; 1; trigger=Yes;

Antibiotic resistance, Hydrolase, Lipid A biosynthesis, Lipid synthesis, Lipopolysaccharide biosynthesis.

GO:0016811; Molecular function: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides.
GO:0009245; Biological process: lipid A biosynthetic process.

Size range:	286-305 amino acids
Related UniRules:	None
Template:	P76472 (ARND_ECOLI)
Scope:	Bacteria; Gammaproteobacteria
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None