HAMAP annotation rule MF_01870
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Accession MF_01870
Dates 3-AUG-2009 (Created)
13-JUL-2012 (Last updated, Version 8)
Name ArnD
Scope Bacteria; Gammaproteobacteria
Triggered by



Identifier
ARND
Protein name
RecName: Full=Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD;
EC=3.5.1.n3;
Gene name
arnD


FUNCTION Catalyzes the deformylation of 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity).
CATALYTIC ACTIVITY 4-deoxy-4-formamido-beta-L-arabinose di-trans,poly-cis-undecaprenyl phosphate + H(2)O = 4-amino-4-deoxy-alpha-L-arabinose di-trans,poly-cis-undecaprenyl phosphate + formate.
PATHWAY Glycolipid biosynthesis; 4-amino-4-deoxy-alpha-L-arabinose undecaprenyl phosphate biosynthesis; 4-amino-4-deoxy-alpha-L-arabinose undecaprenyl phosphate from UDP-4-deoxy-4-formamido-beta-L-arabinose and undecaprenyl phosphate; step 2/2.
Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis.
SIMILARITY Belongs to the polysaccharide deacetylase family. ArnD deformylase subfamily.


Antibiotic resistance
Hydrolase
Lipid A biosynthesis
Lipid biosynthesis
Lipid metabolism
Lipopolysaccharide biosynthesis


GO:0016811; Molecular function: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides.
GO:0009245; Biological process: lipid A biosynthetic process.


Pfam PF01522; Polysacc_deac_1; 1; trigger=Yes;


Size range: 286-305 amino acids
Related Rules: None
Template: P76472 (ARND_ECOLI)
Fusion: None


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