HAMAP rule MF_01881
General rule information
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| Accession | MF_01881 |
| Dates | 23-JUL-2010 (Created)
1-JUN-2023 (Last updated, Version 14) |
| Name | Propion_kin_subfam1 |
| Scope(s) |
Bacteria Enterobacterales |
| Template(s) | P11868 (TDCD_ECOLI); O06961 (TDCD_SALTY); [ Recover all ] |
| Triggered by |
HAMAP; MF_01881 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | TDCD |
| Protein name | RecName: Full=Propionate kinase; EC=2.7.2.15; |
| Gene name | Name=tdcD; |
Comments
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| FUNCTION | Catalyzes the conversion of propionyl phosphate and ADP to propionate and ATP. |
| CATALYTIC ACTIVITY | Reaction=ATP + propanoate = ADP + propanoyl phosphate; Xref=Rhea:RHEA:23148, ChEBI:CHEBI:17272, ChEBI:CHEBI:30616, ChEBI:CHEBI:58933, ChEBI:CHEBI:456216; EC=2.7.2.15; |
| COFACTOR | Name=Mg(2+); Xref=ChEBI:CHEBI:18420; |
| PATHWAY | Amino-acid degradation; L-threonine degradation via propanoate pathway; propanoate from L-threonine: step 4/4. |
| SUBUNIT | Homodimer. |
| SIMILARITY | Belongs to the acetokinase family. TdcD subfamily. |
Keywords
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Gene Ontology
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| GO:0008980; Molecular function:propionate kinase activity |
| GO:0016310; Biological process:phosphorylation |
Cross-references
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| Pfam | PF00871; Acetate_kinase; 1; |
| PRINTS | PR00471; ACETATEKNASE; 1; |
| NCBIfam | TIGR00016; AckA; 1; |
| PIRSF | PIRSF000722; Acetate_prop_kin; 1; |
| PROSITE | PS01075; ACETATE_KINASE_1; 1; |
| PROSITE | PS01076; ACETATE_KINASE_2; 1; |
Features
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| From: TDCD_SALTY (O06961) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 203 | 207 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
H-L-G-N-G | ||||||||
| BINDING | 278 | 280 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
D-[LM]-R | ||||||||
| BINDING | 326 | 330 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
G-I-G-E-N | ||||||||
| ACT_SITE | 143 | 143 | /note="Proton donor/acceptor" | D | ||||||||
| BINDING | 11 | 11 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
N | ||||||||
| BINDING | 381 | 381 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
D | ||||||||
| BINDING | 11 | 11 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
N | ||||||||
| BINDING | 18 | 18 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
K | ||||||||
| BINDING | 86 | 86 | /ligand="substrate" | R | ||||||||
| BINDING | 175 | 175 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
H | ||||||||
| BINDING | 326 | 326 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
G | ||||||||
| SITE | 175 | 175 | /note="Transition state stabilizer" | H | ||||||||
| SITE | 236 | 236 | /note="Transition state stabilizer" | R | ||||||||
Additional information
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| Size range | 372-418 amino acids |
| Related rules |
MF_00020 |
| Fusion | Nter: None Cter: None |