HAMAP

Accession	MF_01884
Dates	4-AUG-2010 (Created) 30-MAY-2011 (Last updated, Version 5)

Data class

Protein

Predictors

HAMAP; MF_01884; [distribution of match scores in UniProtKB];[seed alignment for MF_01884]

Names

Rho

Identifier

RHO

Protein name

RecName: Full=Transcription termination factor Rho; EC=3.6.4.-; AltName: Full=ATP-dependent helicase Rho;

Gene name

rho

FUNCTION: Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity).

SUBUNIT: Homohexamer. The homohexamer assembles into an open ring structure (By similarity).

SIMILARITY: Belongs to the Rho family.

Pfam	PF00006; ATP-synt_ab; 1; PF07498; Rho_N; 1; PF07497; Rho_RNA_bind; 1;
TIGRFAMs	TIGR00767; Rho; 1;

ATP-binding, Helicase, Hydrolase, Nucleotide-binding, RNA-binding, Transcription, Transcription regulation, Transcription termination.

GO:0005524; Molecular function: ATP binding.
GO:0004386; Molecular function: helicase activity.
GO:0003723; Molecular function: RNA binding.
GO:0006353; Biological process: transcription termination, DNA-dependent.

From: RHO_ECOLI (P0AG30)
Key		From		To		Description		Condition		FTGroup
NP_BIND		169		174		ATP (Potential)		G-x-G-x-x-[GAS]
NP_BIND		181		186		ATP (By similarity)		[KR]-x-G-K-[TS]-x
REGION (Optional)		61		66		RNA-binding 1 (By similarity)		G-[FY]-G-[FYR]-[LV]-R		1
REGION (Optional)		78		80		RNA-binding 1 (By similarity)		D-I-[YFR]		1
REGION (Optional)		108		110		RNA-binding 1 (By similarity)		[ED]-R-[YFR]		1
REGION (Optional)		284		288		RNA-binding 2 (By similarity)		[VL]-L-[TS]-G-G		1
BINDING		212		212		ATP (By similarity)		R
SITE (Optional)		326		326		RNA-binding 2 (By similarity)		K		1

Size range:	341-849 amino acids
Related UniRules:	None
Template:	P0AG30 (RHO_ECOLI)
Scope:	Bacteria
Fusion:	Nter: None; Cter: None
Duplicate:	in EHRCR
Plasmid encoded:	None