HAMAP rule MF_01887
General rule information
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Accession | MF_01887 |
Dates | 8-NOV-2010 (Created)
1-JUN-2023 (Last updated, Version 13) |
Name | 23SrRNA_methyltr_B |
Scope(s) |
Bacteria Pseudomonadota |
Template(s) | P63177 (RLMB_ECOLI); [ Recover all ] |
Triggered by |
HAMAP; MF_01887 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | RLMB |
Protein name | RecName: Full=23S rRNA (guanosine-2'-O-)-methyltransferase RlmB; EC=2.1.1.185; AltName: Full=23S rRNA (guanosine2251 2'-O)-methyltransferase; AltName: Full=23S rRNA Gm2251 2'-O-methyltransferase; |
Gene name | Name=rlmB; |
Comments
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FUNCTION | Specifically methylates the ribose of guanosine 2251 in 23S rRNA. |
CATALYTIC ACTIVITY | Reaction=guanosine(2251) in 23S rRNA + S-adenosyl-L-methionine = 2'-O- methylguanosine(2251) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:24140, Rhea:RHEA-COMP:10239, Rhea:RHEA-COMP:10241, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74269, ChEBI:CHEBI:74445; EC=2.1.1.185; |
case <OC:Enterobacterales> | |
SUBUNIT | Homodimer. |
end case | |
SUBCELLULAR LOCATION | Cytoplasm. |
SIMILARITY | Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. RlmB subfamily. |
Keywords
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Gene Ontology
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GO:0070039; Molecular function:rRNA (guanosine-2'-O-)-methyltransferase activity |
GO:0006364; Biological process:rRNA processing |
GO:0005737; Cellular component:cytoplasm |
Cross-references
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Pfam | PF00588; SpoU_methylase; 1; |
Pfam | PF08032; SpoU_sub_bind; 1; |
NCBIfam | TIGR00186; RRNA_methyl_3; 1; |
Features
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From: RLMB_ECOLI (P63177) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 196 | 196 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
G | ||||||||
BINDING | 216 | 216 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
[IL] | ||||||||
BINDING | 225 | 225 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
[LM] |
Additional information
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Size range | 231-284 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |