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Annotation rule MF_01903
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General rule information [?]

Accession MF_01903
Dates 6-DEC-2005 (Created)
10-OCT-2014 (Last updated, Version 23)
Name XGPRT
Scope Bacteria; Proteobacteria
Template P0A9M5 (XGPT_ECOLI)

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
XGPT
Protein name
RecName: Full=Xanthine phosphoribosyltransferase;
EC=2.4.2.22;
AltName: Full=Xanthine-guanine phosphoribosyltransferase;
Short=XGPRT;
Gene name
gpt

Comments [?]

Function Acts on guanine, xanthine and to a lesser extent hypoxanthine.
Catalytic activity XMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + xanthine.
Cofactor Mg(2+)
Note: Binds 1 Mg(2+) ion per subunit.
Pathway Purine metabolism; XMP biosynthesis via salvage pathway; XMP from xanthine: step 1/1.
Subunit Homotetramer.
case not defined <Property:Membrane> or <Property:Membrane=1>
Subcellular location Cell membrane; Peripheral membrane protein.
else case <Property:Membrane=2>
Subcellular location Cell inner membrane; Peripheral membrane protein.
end case
Similarity Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily.

Keywords [?]

case defined <Property:Membrane> and <Property:Membrane=2>
end case

Gene Ontology [?]

GO:0000287; Molecular function: magnesium ion binding.
GO:0000310; Molecular function: xanthine phosphoribosyltransferase activity.
GO:0006166; Biological process: purine ribonucleoside salvage.
GO:0005886; Cellular component: plasma membrane.

Cross-references [?]

PROSITE PS00103; PUR_PYR_PR_TRANSFER; 1;
Pfam PF00156; Pribosyltran; 1;

Features [?]

From: XGPT_ECOLI (P0A9M5)
Key     From     To       Description   Tag   Condition   FTGroup
REGION     37     38       5-phosphoribose 1-diphosphate binding     R-G  
REGION     92     96       5-phosphoribose 1-diphosphate binding     D-[TS]-G-X-T  
METAL     89     89       Magnesium     D  
BINDING     69     69       5-phosphoribose 1-diphosphate     R  
BINDING     92     92       Xanthine     D  
BINDING     135     135       Xanthine; via amide nitrogen and carbonyl oxygen     I  

Additional information [?]

Size range 152-176 amino acids
Related rules None
Fusion None