HAMAP rule MF_01917
General rule information
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Accession | MF_01917 |
Dates | 16-APR-2014 (Created)
26-JAN-2023 (Last updated, Version 6) |
Name | Cardiolipin_synth_ClsB |
Scope(s) |
Bacteria Pseudomonadota |
Template(s) | P0AA84 (CLSB_ECOLI); [ Recover all ] |
Triggered by |
HAMAP; MF_01917 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | CLSB |
Protein name | RecName: Full=Cardiolipin synthase B; Short=CL synthase; EC=2.7.8.-; |
Gene name | Name=clsB; |
Comments
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FUNCTION | Catalyzes the phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol. |
CATALYTIC ACTIVITY | Reaction=2 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) = a cardiolipin + glycerol; Xref=Rhea:RHEA:31451, ChEBI:CHEBI:17754, ChEBI:CHEBI:62237, ChEBI:CHEBI:64716; |
SUBCELLULAR LOCATION | Cell membrane; Peripheral membrane protein. |
SIMILARITY | Belongs to the phospholipase D family. Cardiolipin synthase subfamily. ClsB sub-subfamily. |
Keywords
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Cell membrane |
Lipid biosynthesis |
Lipid metabolism |
Membrane |
Phospholipid biosynthesis |
Phospholipid metabolism |
Transferase |
Gene Ontology
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GO:0016780; Molecular function:phosphotransferase activity, for other substituted phosphate groups |
GO:0008654; Biological process:phospholipid biosynthetic process |
GO:0005886; Cellular component:plasma membrane |
Cross-references
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Features
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From: CLSB_ECOLI (P0AA84) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
ACT_SITE | 113 | 113 | H | |||||||||
ACT_SITE | 115 | 115 | K | |||||||||
ACT_SITE | 120 | 120 | D | |||||||||
ACT_SITE | 290 | 290 | H | |||||||||
ACT_SITE | 292 | 292 | K | |||||||||
ACT_SITE | 297 | 297 | D |
Additional information
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Size range | 370-460 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |