HAMAP rule MF_01927
General rule information
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| Accession | MF_01927 |
| Dates | 10-JUL-2014 (Created)
18-JUL-2023 (Last updated, Version 6) |
| Name | PurU |
| Scope(s) |
Bacteria |
| Template(s) | P37051 (PURU_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_01927 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | PURU |
| Protein name | RecName: Full=Formyltetrahydrofolate deformylase; EC=3.5.1.10; AltName: Full=Formyl-FH(4) hydrolase; |
| Gene name | Name=purU; |
Comments
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| FUNCTION | Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). |
| CATALYTIC ACTIVITY | Reaction=(6R)-10-formyltetrahydrofolate + H2O = (6S)-5,6,7,8- tetrahydrofolate + formate + H(+); Xref=Rhea:RHEA:19833, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15740, ChEBI:CHEBI:57453, ChEBI:CHEBI:195366; EC=3.5.1.10; |
| PATHWAY | Purine metabolism; IMP biosynthesis via de novo pathway; formate from 10-formyl-5,6,7,8-tetrahydrofolate: step 1/1. |
| SIMILARITY | Belongs to the PurU family. |
Keywords
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Gene Ontology
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| GO:0008864; Molecular function:formyltetrahydrofolate deformylase activity |
| GO:0006189; Biological process:'de novo' IMP biosynthetic process |
Cross-references
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| PROSITE | PS51671; ACT; 1; |
| Pfam | PF01842; ACT; 1; |
| Pfam | PF00551; Formyl_trans_N; 1; |
| PRINTS | PR01575; FFH4HYDRLASE; 1; |
| NCBIfam | TIGR00655; PurU; 1; |
| PIRSF | PIRSF036480; FormyFH4_hydr; 1; |
Features
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| From: PURU_ECOLI (P37051) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 225 | 225 | D | |||||||||
Additional information
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| Size range | 230-340 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |