HAMAP rule MF_01928

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_01928
Accession	MF_01928
Dates	21-AUG-2014 (Created) 3-SEP-2024 (Last updated, Version 9)
Name	PurK
Scope(s)	Bacteria Archaea
Template(s)	P09029 (PURK_ECOLI); [ Recover all ]
Triggered by	HAMAP; MF_01928 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	PURK
Protein name	RecName: Full=N5-carboxyaminoimidazole ribonucleotide synthase; Short=N5-CAIR synthase; EC=6.3.4.18; AltName: Full=5-(carboxyamino)imidazole ribonucleotide synthetase;
Gene name	Name=purK;

Comments [?]

FUNCTION	Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
CATALYTIC ACTIVITY	Reaction=5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + hydrogencarbonate + ATP = 5-carboxyamino-1-(5-phospho-D- ribosyl)imidazole + ADP + phosphate + 2 H(+); Xref=Rhea:RHEA:19317, ChEBI:CHEBI:15378, ChEBI:CHEBI:17544, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:58730, ChEBI:CHEBI:137981, ChEBI:CHEBI:456216; EC=6.3.4.18;
PATHWAY	Purine metabolism; IMP biosynthesis via de novo pathway; 5- amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5- phospho-D-ribosyl)imidazole (N5-CAIR route): step 1/2.
SUBUNIT	Homodimer.
SIMILARITY	Belongs to the PurK/PurT family.

Keywords [?]

Gene Ontology [?]

GO:0034028; Molecular function:5-(carboxyamino)imidazole ribonucleotide synthase activity

GO:0006189; Biological process:'de novo' IMP biosynthetic process

Cross-references [?]

Features [?]

From: PURK_ECOLI (P09029)

Key

From

Description

Tag

Condition

FTGroup

case <Feature:PS50975>

DOMAIN

267

/note="ATP-grasp"

end case

BINDING

125

131