HAMAP rule MF_01929
General rule information
[?]
| Accession | MF_01929 |
| Dates | 25-AUG-2014 (Created)
1-JUN-2023 (Last updated, Version 7) |
| Name | PurE_classI |
| Scope(s) |
Bacteria Archaea |
| Template(s) | P0AG18 (PURE_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_01929 (Get profile general information and statistics) |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
| Identifier | PURE |
| Protein name | RecName: Full=N5-carboxyaminoimidazole ribonucleotide mutase; Short=N5-CAIR mutase; EC=5.4.99.18; AltName: Full=5-(carboxyamino)imidazole ribonucleotide mutase; |
| Gene name | Name=purE; |
Comments
[?]
| FUNCTION | Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). |
| CATALYTIC ACTIVITY | Reaction=5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + H(+) = 5- amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate; Xref=Rhea:RHEA:13193, ChEBI:CHEBI:15378, ChEBI:CHEBI:58730, ChEBI:CHEBI:77657; EC=5.4.99.18; |
| PATHWAY | Purine metabolism; IMP biosynthesis via de novo pathway; 5- amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5- phospho-D-ribosyl)imidazole (N5-CAIR route): step 2/2. |
| SIMILARITY | Belongs to the AIR carboxylase family. Class I subfamily. |
Keywords
[?]
Gene Ontology
[?]
| GO:0034023; Molecular function:5-(carboxyamino)imidazole ribonucleotide mutase activity |
| GO:0006189; Biological process:'de novo' IMP biosynthetic process |
Cross-references
[?]
| Pfam | PF00731; AIRC; 1; |
| NCBIfam | TIGR01162; purE; 1; |
| PIRSF | PIRSF001338; AIR_carboxylase; 1; |
Features
[?]
| From: PURE_ECOLI (P0AG18) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 16 | 16 | /ligand="substrate" | S | ||||||||
| BINDING | 19 | 19 | /ligand="substrate" | D | ||||||||
| BINDING | 46 | 46 | /ligand="substrate" | R | ||||||||
Additional information
[?]
| Size range | 157-339 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | See rule MF_02045 for prokaryotic class II PurEs. Class I and class II PurEs are mechanistically related but bind different substrates. |