HAMAP rule MF_01934
General rule information
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| Accession | MF_01934 |
| Dates | 8-OCT-2014 (Created)
1-JUN-2023 (Last updated, Version 13) |
| Name | MenB |
| Scope(s) |
Bacteria Archaea |
| Template(s) | P0ABU0 (MENB_ECOLI); P23966 (MENB_BACSU); A0QRD3 (MENB_MYCS2); P9WNP5 (MENB_MYCTU); Q7CQ56 (MENB_SALTY); Q5HH38 (MENB_STAAC); [ Recover all ] |
| Triggered by |
HAMAP; MF_01934 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | MENB |
| Protein name | RecName: Full=1,4-dihydroxy-2-naphthoyl-CoA synthase; Short=DHNA-CoA synthase; EC=4.1.3.36; |
| Gene name | Name=menB; |
Comments
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| FUNCTION | Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2- naphthoyl-CoA (DHNA-CoA). |
| CATALYTIC ACTIVITY | Reaction=2-succinylbenzoyl-CoA + H(+) = 1,4-dihydroxy-2-naphthoyl-CoA + H2O; Xref=Rhea:RHEA:26562, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57364, ChEBI:CHEBI:58897; EC=4.1.3.36; |
| case <FTTag:hydrogencarbonate> | |
| COFACTOR | Name=hydrogencarbonate; Xref=ChEBI:CHEBI:17544; |
| end case | |
| PATHWAY | Quinol/quinone metabolism; 1,4-dihydroxy-2-naphthoate biosynthesis; 1,4-dihydroxy-2-naphthoate from chorismate: step 6/7. |
| case not <OC:Cyanobacteriota> | |
| PATHWAY | Quinol/quinone metabolism; menaquinone biosynthesis. |
| else case <OC:Cyanobacteriota> | |
| PATHWAY | Cofactor biosynthesis; phylloquinone biosynthesis. |
| end case | |
| SIMILARITY | Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily. |
Keywords
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| Lyase | |
| case not <OC:Cyanobacteriota> | |
| Menaquinone biosynthesis | |
| end case | |
Gene Ontology
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| GO:0008935; Molecular function:1,4-dihydroxy-2-naphthoyl-CoA synthase activity | |
| case not <OCellular component:Cyanobacteriota> | |
| GO:0009234; Biological process:menaquinone biosynthetic process | |
| else case <OCellular component:Cyanobacteriota> | |
| GO:0042372; Biological process:phylloquinone biosynthetic process | |
| end case | |
Cross-references
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Features
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| From: MENB_ECOLI (P0ABU0) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 84 | 88 | /ligand="substrate" /ligand_note="ligand shared between two neighboring subunits" /note="in other chain" |
[SAVT]-G-G-[DN]-Q | ||||||||
| BINDING | 129 | 133 | /ligand="substrate" /ligand_note="ligand shared between two neighboring subunits" /note="in other chain" |
|||||||||
| BINDING | 154 | 156 | /ligand="hydrogencarbonate" /ligand_id="ChEBI:CHEBI:17544" |
hydrogencarbonate | Q-T-G | |||||||
| BINDING | 45 | 45 | /ligand="substrate" /ligand_note="ligand shared between two neighboring subunits" /note="in other chain" |
R | ||||||||
| BINDING | 97 | 97 | /ligand="substrate" /ligand_note="ligand shared between two neighboring subunits" /note="in other chain" |
Y | ||||||||
| BINDING | 155 | 155 | /ligand="substrate" /ligand_note="ligand shared between two neighboring subunits" /note="in other chain" |
T | ||||||||
| BINDING | 161 | 161 | /ligand="substrate" /ligand_note="ligand shared between two neighboring subunits" /note="in other chain" |
S | ||||||||
| BINDING | 258 | 258 | /ligand="substrate" /ligand_note="ligand shared between two neighboring subunits" |
Y | ||||||||
| BINDING | 273 | 273 | /ligand="substrate" /ligand_note="ligand shared between two neighboring subunits" |
K | ||||||||
| SITE | 97 | 97 | /note="Important for catalysis" | Y | ||||||||
| SITE | 258 | 258 | /note="Important for catalysis" | Y | ||||||||
| From: MENB_MYCTU (P9WNP5) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| SITE | 185 | 185 | /note="Important for catalysis" | D | ||||||||
Additional information
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| Size range | 250-391 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | The hydrogencarbonate anion plays the same catalytic role (proton acceptor) as the side-chain carboxylate group of the essential 'Asp-185' found in actinobacteria, archaea, bacteroidetes, and deltaproteobacteria. |