HAMAP rule MF_01936
General rule information
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Accession | MF_01936 |
Dates | 23-OCT-2014 (Created)
1-JUN-2023 (Last updated, Version 7) |
Name | MenI |
Scope(s) |
Bacteria Enterobacterales |
Template(s) | P77781 (MENI_ECOLI); [ Recover all ] |
Triggered by |
HAMAP; MF_01936 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | MENI |
Protein name | RecName: Full=1,4-dihydroxy-2-naphthoyl-CoA hydrolase; Short=DHNA-CoA hydrolase; EC=3.1.2.28; AltName: Full=DHNA-CoA thioesterase; |
Gene name | Name=menI; |
Comments
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FUNCTION | Catalyzes the hydrolysis of 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA) to 1,4-dihydroxy-2-naphthoate (DHNA). |
CATALYTIC ACTIVITY | Reaction=1,4-dihydroxy-2-naphthoyl-CoA + H2O = 1,4-dihydroxy-2- naphthoate + CoA + H(+); Xref=Rhea:RHEA:26309, ChEBI:CHEBI:11173, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:58897; EC=3.1.2.28; |
PATHWAY | Quinol/quinone metabolism; 1,4-dihydroxy-2-naphthoate biosynthesis; 1,4-dihydroxy-2-naphthoate from chorismate: step 7/7. |
PATHWAY | Quinol/quinone metabolism; menaquinone biosynthesis. |
SUBUNIT | Homotetramer. Dimer of dimers. |
SIMILARITY | Belongs to the thioesterase PaaI family. |
Keywords
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Gene Ontology
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GO:0016790; Molecular function:thiolester hydrolase activity |
GO:0009234; Biological process:menaquinone biosynthetic process |
Cross-references
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Features
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From: MENI_ECOLI (P77781) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 89 | 92 | /ligand="substrate" | H-[VIL]-[RK]-[SA] | ||||||||
BINDING | 106 | 111 | /ligand="substrate" | H-[VL]-G-[SAT]-R-H | ||||||||
ACT_SITE | 63 | 63 | /note="Nucleophile or proton acceptor" | E | ||||||||
BINDING | 82 | 82 | /ligand="substrate" | G |
Additional information
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Size range | 130-160 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |
Comments | The profile and the rule are currently restricted to Enterobacterales. Further characterization is needed for other species. |