HAMAP rule MF_01938
General rule information
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PURL | https://purl.expasy.org/hamap/rule/MF_01938 |
Accession | MF_01938 |
Dates | 28-OCT-2014 (Created)
10-OCT-2024 (Last updated, Version 9) |
Name | MenA_2 |
Scope(s) |
Bacteria Cyanobacteriota |
Template(s) | P73962 (MENA_SYNY3); [ Recover all ] |
Triggered by |
HAMAP; MF_01938 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | MENA |
Protein name | RecName: Full=2-carboxy-1,4-naphthoquinone phytyltransferase; EC=2.5.1.130; AltName: Full=1,4-dihydroxy-2-naphthoate phytyltransferase; Short=DHNA phytyltransferase; |
Gene name | Name=menA; |
Comments
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FUNCTION | Involved in the synthesis of phylloquinone (vitamin K1). Catalyzes the transfer of a prenyl chain to 2-carboxy-1,4- naphthoquinone. |
CATALYTIC ACTIVITY | Reaction=2-carboxy-1,4-naphthoquinone + phytyl diphosphate + H(+) = demethylphylloquinone + CO2 + diphosphate; Xref=Rhea:RHEA:47740, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:31087, ChEBI:CHEBI:33019, ChEBI:CHEBI:75434, ChEBI:CHEBI:87842; EC=2.5.1.130; |
PATHWAY | Cofactor biosynthesis; phylloquinone biosynthesis. |
SUBCELLULAR LOCATION | Cell inner membrane; Multi-pass membrane protein. |
SIMILARITY | Belongs to the MenA family. Type 2 subfamily. |
Keywords
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Gene Ontology
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GO:0016765; Molecular function:transferase activity, transferring alkyl or aryl (other than methyl) groups |
GO:0042372; Biological process:phylloquinone biosynthetic process |
GO:0005886; Cellular component:plasma membrane |
Cross-references
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Pfam | PF01040; UbiA; 1; |
NCBIfam | TIGR02235; menA_cyano-plnt; 1; |
PIRSF | PIRSF005355; UBIAD1; 1; |
General | Transmembrane; -; 7-9; |
Features
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Additional information
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Size range | 277-340 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |