HAMAP rule MF_01940
General rule information
[?]
| Accession | MF_01940 |
| Dates | 28-NOV-2014 (Created)
1-JUN-2023 (Last updated, Version 6) |
| Name | RNA_CPDase |
| Scope(s) |
Bacteria Archaea |
| Template(s) | P37025 (THPR_ECOLI); Q8U4Q3 (THPR_PYRFU); Q5SHB1 (THPR_THET8); [ Recover all ] |
| Triggered by |
HAMAP; MF_01940 (Get profile general information and statistics) |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
| Identifier | THPR |
| Protein name | RecName: Full=RNA 2',3'-cyclic phosphodiesterase; Short=RNA 2',3'-CPDase; EC=3.1.4.58; |
| case <OC:Escherichia> or <OC:Shigella> | |
| Gene name | Name=thpR; |
| end case | |
Comments
[?]
| FUNCTION | Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester. |
| CATALYTIC ACTIVITY | Reaction=a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + H2O = a 3'- end 2'-phospho-ribonucleotide-RNA + H(+); Xref=Rhea:RHEA:11828, Rhea:RHEA-COMP:10464, Rhea:RHEA-COMP:17353, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:83064, ChEBI:CHEBI:173113; EC=3.1.4.58; |
| SIMILARITY | Belongs to the 2H phosphoesterase superfamily. ThpR family. |
Keywords
[?]
Gene Ontology
[?]
| GO:0008081; Molecular function:phosphoric diester hydrolase activity |
Cross-references
[?]
Features
[?]
| From: THPR_ECOLI (P37025) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| MOTIF | 43 | 46 | /note="HXTX 1" | H-x-T-x | ||||||||
| MOTIF | 125 | 128 | /note="HXTX 2" | H-x-T-x | ||||||||
| ACT_SITE | 43 | 43 | /note="Proton donor" | H | ||||||||
| ACT_SITE | 125 | 125 | /note="Proton acceptor" | H | ||||||||
Additional information
[?]
| Size range | 153-320 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | Was originally thought to be a 2',5'-RNA ligase. |