HAMAP annotation rule: MF_01959
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Accession MF_01959
Dates 12-MAY-2006 (Created)
22-DEC-2010 (Last updated, Version 21)
Data class Protein
Names CcmE



Identifier CCME
Protein name
RecName: Full=Cytochrome c-type biogenesis protein CcmE;
AltName: Full=Cytochrome c maturation protein E;
AltName: Full=Heme chaperone CcmE;
Gene name ccmE, cycJ
FUNCTION: Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity).

case not defined <Property:Membrane> or <Property:Membrane=1>
SUBCELLULAR LOCATION: Cell membrane; Single-pass type II membrane protein (Potential).

else case <Property:Membrane=2>
SUBCELLULAR LOCATION: Cell inner membrane; Single-pass type II membrane protein; Periplasmic side (Potential).
end case

SIMILARITY: Belongs to the CcmE/CycJ family.
Pfam PF03100; CcmE; 1;

case defined <Property:Membrane> and <Property:Membrane=2>
end case

GO:0017003; Biological process: protein-heme linkage.
GO:0005886; Cellular component: plasma membrane.
From: CCME_ECOLI (P69490)
Key     From     To       Description   Condition   FTGroup
TOPO_DOM     Nter     8       Cytoplasmic (Potential)      
TRANSMEM     9     29       Helical; Signal-anchor for type II membrane protein; (Potential)      
case not defined <Property:Membrane> or <Property:Membrane=1>
Key     From     To       Description   Condition   FTGroup
TOPO_DOM     30     Cter       Extracellular (Potential)      
end case

case defined <Property:Membrane> and <Property:Membrane=2>
Key     From     To       Description   Condition   FTGroup
TOPO_DOM     30     Cter       Periplasmic (Potential)      
end case

Key     From     To       Description   Condition   FTGroup
METAL     134     134       Iron (heme axial ligand) (By similarity)   Y  
BINDING     130     130       Heme (covalent; via pros nitrogen) (By similarity)   H  



Size range: 128-181 amino acids
Related UniRules: None
Template: P69490 (CCME_ECOLI); Q8EK44 (CCME_SHEON): [Recover all]
Scope: Bacteria; Deinococci
Bacteria; Proteobacteria
Fusion: Nter: None; Cter: None
Duplicate: in PSEPF, RHIEC, SALCH, SALPA, SALTI, SALTY, SILPO, XANAC, XANC5, XANC8, XANCP, XANOM, XANOR
Plasmid encoded: in CUPNH, RHIEC, RHIET, SILPO
Comments: In SALCH, the duplicated copy ccmE2 is fused to ccmA2, however, important parts of the proteins are missing and it is therefore probably not functional. May be a pseudogene.

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