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| HAMAP annotation rule MF_01959 |
| Accession |
MF_01959 |
| Dates |
12-MAY-2006 (Created)
9-NOV-2012 (Last updated, Version 22) |
| Scope |
Bacteria; Deinococci
Bacteria; Proteobacteria |
| Protein name |
|
RecName:
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Full=Cytochrome c-type biogenesis protein CcmE;
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AltName:
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Full=Cytochrome c maturation protein E;
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AltName:
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Full=Heme chaperone CcmE;
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| FUNCTION |
Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity). |
case not defined <Property:Membrane> or <Property:Membrane=1>
| SUBCELLULAR LOCATION |
Cell membrane; Single-pass type II membrane protein (Potential). |
else case <Property:Membrane=2>
| SUBCELLULAR LOCATION |
Cell inner membrane; Single-pass type II membrane protein; Periplasmic side (Potential). |
end case
| SIMILARITY |
Belongs to the CcmE/CycJ family. |
case defined <Property:Membrane> and <Property:Membrane=2>
end case
GO:0017003; Biological process: protein-heme linkage.
GO:0005886; Cellular component: plasma membrane.
| From: CCME_ECOLI (P69490) |
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Key
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From
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To
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Description
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Tag
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Condition
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FTGroup
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TOPO_DOM
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Nter
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8
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Cytoplasmic (Potential)
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|
|
|
|
|
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TRANSMEM
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9
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29
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Helical; Signal-anchor for type II membrane protein; (Potential)
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|
|
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|
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case not defined <Property:Membrane> or <Property:Membrane=1>
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TOPO_DOM
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30
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Cter
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Extracellular (Potential)
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|
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|
|
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end case
case defined <Property:Membrane> and <Property:Membrane=2>
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TOPO_DOM
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30
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Cter
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Periplasmic (Potential)
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|
|
|
|
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|
end case
|
METAL
|
|
134
|
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134
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Iron (heme axial ligand) (By similarity)
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Y
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BINDING
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130
|
|
130
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Heme (covalent; via pros nitrogen) (By similarity)
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|
H
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| Size range: |
128-181 amino acids |
| Related Rules: |
None |
| Templates: |
P69490 (CCME_ECOLI); Q8EK44 (CCME_SHEON): [Recover all] |
| Fusion: |
None |
| Comments: |
In SALCH, the duplicated copy ccmE2 is fused to ccmA2, however, important parts of the proteins are missing and it is therefore probably not functional. May be a pseudogene. |