Annotation rule MF_01959
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General rule information [?]

Accession MF_01959
Dates 12-MAY-2006 (Created)
9-NOV-2012 (Last updated, Version 22)
Name CcmE
Scope Bacteria; Deinococci
Bacteria; Proteobacteria

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Cytochrome c-type biogenesis protein CcmE;
AltName: Full=Cytochrome c maturation protein E;
AltName: Full=Heme chaperone CcmE;
Gene name
ccmE, cycJ

Comments [?]

Function Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity).
case not defined <Property:Membrane> or <Property:Membrane=1>
Subcellular location Cell membrane; Single-pass type II membrane protein (Potential).
else case <Property:Membrane=2>
Subcellular location Cell inner membrane; Single-pass type II membrane protein; Periplasmic side (Potential).
end case
Similarity Belongs to the CcmE/CycJ family.

Keywords [?]

case defined <Property:Membrane> and <Property:Membrane=2>
end case

Gene Ontology [?]

GO:0017003; Biological process: protein-heme linkage.
GO:0005886; Cellular component: plasma membrane.

Cross-references [?]

Pfam PF03100; CcmE; 1;

Features [?]

From: CCME_ECOLI (P69490)
Key     From     To       Description   Tag   Condition   FTGroup
TOPO_DOM     Nter     8       Cytoplasmic (Potential)        
TRANSMEM     9     29       Helical; Signal-anchor for type II membrane protein; (Potential)        
case not defined <Property:Membrane> or <Property:Membrane=1>
TOPO_DOM     30     Cter       Extracellular (Potential)        
end case
case defined <Property:Membrane> and <Property:Membrane=2>
TOPO_DOM     30     Cter       Periplasmic (Potential)        
end case
METAL     134     134       Iron (heme axial ligand) (By similarity)     Y  
BINDING     130     130       Heme (covalent; via pros nitrogen) (By similarity)     H  

Additional information [?]

Size range 128-181 amino acids
Related rules None
Templates P69490 (CCME_ECOLI); Q8EK44 (CCME_SHEON): [Recover all]
Fusion None
Comments In SALCH, the duplicated copy ccmE2 is fused to ccmA2, however, important parts of the proteins are missing and it is therefore probably not functional. May be a pseudogene.