HAMAP

Accession	MF_01959
Dates	12-MAY-2006 (Created) 22-DEC-2010 (Last updated, Version 21)

Data class

Protein

Predictors

HAMAP; MF_01959; [distribution of match scores in UniProtKB];[seed alignment for MF_01959]

Names

CcmE

Identifier

CCME

Protein name

RecName: Full=Cytochrome c-type biogenesis protein CcmE; AltName: Full=Cytochrome c maturation protein E; AltName: Full=Heme chaperone CcmE;

Gene name

ccmE, cycJ

FUNCTION: Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity).

SUBCELLULAR LOCATION: Cell membrane; Single-pass type II membrane protein (Potential).

SUBCELLULAR LOCATION: Cell inner membrane; Single-pass type II membrane protein; Periplasmic side (Potential).

SIMILARITY: Belongs to the CcmE/CycJ family.

Pfam	PF03100; CcmE; 1;

Cytochrome c-type biogenesis, Heme, Cell membrane.

Cell inner membrane.

Iron, Membrane, Metal-binding, Transmembrane, Signal-anchor, Transmembrane helix.

GO:0017003; Biological process: protein-heme linkage.
GO:0005886; Cellular component: plasma membrane.

From: CCME_ECOLI (P69490)
Key		From		To		Description		Condition		FTGroup
TOPO_DOM		Nter		8		Cytoplasmic (Potential)
TRANSMEM		9		29		Helical; Signal-anchor for type II membrane protein; (Potential)

Key		From		To		Description		Condition		FTGroup
TOPO_DOM		30		Cter		Extracellular (Potential)

Key		From		To		Description		Condition		FTGroup
TOPO_DOM		30		Cter		Periplasmic (Potential)

Key		From		To		Description		Condition		FTGroup
METAL		134		134		Iron (heme axial ligand) (By similarity)		Y
BINDING		130		130		Heme (covalent; via pros nitrogen) (By similarity)		H

Size range:	128-181 amino acids
Related UniRules:	None
Template:	P69490 (CCME_ECOLI); Q8EK44 (CCME_SHEON): [Recover all]
Scope:	Bacteria; Deinococci Bacteria; Proteobacteria
Fusion:	Nter: None; Cter: None
Duplicate:	in PSEPF, RHIEC, SALCH, SALPA, SALTI, SALTY, SILPO, XANAC, XANC5, XANC8, XANCP, XANOM, XANOR
Plasmid encoded:	in CUPNH, RHIEC, RHIET, SILPO
Comments:	In SALCH, the duplicated copy ccmE2 is fused to ccmA2, however, important parts of the proteins are missing and it is therefore probably not functional. May be a pseudogene.