HAMAP rule MF_01960
General rule information
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| Accession | MF_01960 |
| Dates | 6-SEP-2006 (Created)
14-MAY-2022 (Last updated, Version 14) |
| Name | D_aminopeptidase |
| Scope(s) |
Bacteria Alphaproteobacteria |
| Template(s) | Q9ZBA9 (DAP_BRUAN); [ Recover all ] |
| Triggered by |
HAMAP; MF_01960 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | DAP |
| Protein name | RecName: Full=D-aminopeptidase; EC=3.4.11.19; |
| Gene name | Name=dap; |
Comments
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| FUNCTION | Hydrolyzes N-terminal residues in D-amino acid-containing peptides. |
| CATALYTIC ACTIVITY | Reaction=Release of an N-terminal D-amino acid from a peptide, Xaa-|- Yaa-, in which Xaa is preferably D-Ala, D-Ser or D-Thr. D-amino acid amides and methyl esters also are hydrolyzed, as is glycine amide.; EC=3.4.11.19; |
| ACTIVITY REGULATION | Inhibited by beta-lactam compounds such as 6- aminopenicillic acid, 7-aminocephalosporanic acid, benzylpenicillin and ampicillin. Inhibited by p-chloromercuribenzoate. |
| SUBUNIT | Homodimer. |
| SIMILARITY | Belongs to the peptidase S12 family. |
Keywords
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Gene Ontology
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| GO:0004177; Molecular function:aminopeptidase activity |
Cross-references
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Features
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| From: DAP_BRUAN (Q9ZBA9) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| REGION | 477 | 487 | /note="Important for specificity" | |||||||||
| ACT_SITE | 62 | 62 | /note="Nucleophile" | S | ||||||||
| ACT_SITE | 65 | 65 | /note="Proton donor/acceptor" | K | ||||||||
| BINDING | 481 | 481 | /ligand="substrate" | D | ||||||||
Additional information
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| Size range | 516-525 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |