HAMAP

Accession	MF_01960
Dates	6-SEP-2006 (Created) 25-NOV-2009 (Last updated, Version 6)

Data class

Protein

Predictors

HAMAP; MF_01960; [distribution of match scores in UniProtKB];[seed alignment for MF_01960]

Names

D_aminopeptidase

Identifier

DAP

Protein name

RecName: Full=D-aminopeptidase; EC=3.4.11.19;

Gene name

dap

FUNCTION: Hydrolyzes N-terminal residues in D-amino acid-containing peptides (By similarity).

CATALYTIC ACTIVITY: Release of an N-terminal D-amino acid from a peptide, Xaa-|-Yaa-, in which Xaa is preferably D-Ala, D-Ser or D-Thr. D-amino acid amides and methyl esters also are hydrolyzed, as is glycine amide.

ENZYME REGULATION: Inhibited by beta-lactam compounds such as 6-aminopenicillic acid, 7-aminocephalosporanic acid, benzylpenicillin and ampicillin. Inhibited by p-chloromercuribenzoate (By similarity).

SUBUNIT: Homodimer (By similarity).

SIMILARITY: Belongs to the peptidase S12 family.

Pfam	PF00144; Beta-lactamase; 1; PF07930; DAP_B; 1; PF07932; DAP_C; 1;

Aminopeptidase, Hydrolase, Protease.

GO:0004177; Molecular function: aminopeptidase activity.

From: DAP_OCHAN (Q9ZBA9)
Key		From		To		Description		Condition		FTGroup
REGION		477		487		Important for specificity (By similarity)
ACT_SITE		62		62		By similarity		S
ACT_SITE		65		65		By similarity		K
BINDING		481		481		Substrate (By similarity)		D

Size range:	516-525 amino acids
Related UniRules:	None
Template:	Q9ZBA9 (DAP_OCHAN)
Scope:	Bacteria; Alphaproteobacteria
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None