HAMAP

Accession	MF_01961
Dates	23-OCT-2008 (Created) 11-JUL-2011 (Last updated, Version 11)

Data class

Protein

Predictors

HAMAP; MF_01961; [distribution of match scores in UniProtKB];[seed alignment for MF_01961]

Names

Catal-peroxid

Identifier

KATG

Protein name

RecName: Full=Catalase-peroxidase; Short=CP; EC=1.11.1.21; AltName: Full=Peroxidase/catalase;

Gene name

katG

FUNCTION: Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity (By similarity).

CATALYTIC ACTIVITY: Donor + H(2)O(2) = oxidized donor + 2 H(2)O.

CATALYTIC ACTIVITY: 2 H(2)O(2) = O(2) + 2 H(2)O.

COFACTOR: Binds 1 heme B (iron-protoporphyrin IX) group per dimer (By similarity).

SUBUNIT: Homodimer or homotetramer (By similarity).

PTM: The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme (By similarity).

SIMILARITY: Belongs to the peroxidase family. Peroxidase/catalase subfamily.

PROSITE	PS00435; PEROXIDASE_1; 1; PS00436; PEROXIDASE_2; 1; PS50873; PEROXIDASE_4; 1;
Pfam	PF00141; peroxidase; 2;
PRINTS	PR00460; BPEROXIDASE; 1; PR00458; PEROXIDASE; 1;
TIGRFAMs	TIGR00198; Cat_per_HPI; 1;
General	Signal; -; 0-1; trigger=Yes;

Heme, Hydrogen peroxide, Iron, Metal-binding, Oxidoreductase, Peroxidase.

GO:0004096; Molecular function: catalase activity.
GO:0004601; Molecular function: peroxidase activity.

From: KATG_ECOLI (P13029)
Key		From		To		Description		Condition		FTGroup
ACT_SITE		106		106		Proton acceptor (By similarity)		H
METAL		267		267		Iron (heme axial ligand) (By similarity)		H
SITE		102		102		Transition state stabilizer (By similarity)		R
CROSSLNK		105		226		Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with #{Met-252}) (By similarity)		W-x*-Y
CROSSLNK		226		252		Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with #{Trp-105}) (By similarity)		Y-x*-M

Size range:	699-781 amino acids
Related UniRules:	None
Template:	P13029 (KATG_ECOLI); O59651 (KATG2_HALMA); Q939D2 (KATG_BURPS); Q08129 (KATG_MYCTU); Q31MN3 (KATG_SYNE7): [Recover all]
Scope:	Bacteria Archaea; Euryarchaeota
Fusion:	Nter: None; Cter: None
Duplicate:	in ALKMQ, BURA4, BURCA, BURCC, BURCH, BURCJ, BURCM, BURVG, CELJU, ECO57, HALMA, IDILO, LEGPA, LEGPC, LEGPH, LEGPL, LEGPN, MYCFO, MYCS2, MYCVP, CUPPJ, SHEAM, SHEFN, SHEON, SHESA, SHESM, SHESR, VIBPA
Plasmid encoded:	in DINSH, ECO57, ECOLX, HALS3, HALSA, RALME, RHIE6, RHIEC, RHIET, RHIL3, RHIME, RHISN, RHOS5, SILPO, SINMW