Annotation rule MF_01964
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General rule information [?]

Accession MF_01964
Dates 5-JAN-2012 (Created)
22-AUG-2012 (Last updated, Version 4)
Name IMPDH
Scope Archaea
Bacteria
case <OC:Bacteria> or <OC:Archaea>
end case


Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
IMDH
Protein name
RecName: Full=Inosine-5'-monophosphate dehydrogenase;
Short=IMP dehydrogenase;
Short=IMPD;
Short=IMPDH;
EC=1.1.1.205;
Gene name
guaB

Comments [?]

Function Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity).
Catalytic activity Inosine 5'-phosphate + NAD(+) + H(2)O = xanthosine 5'-phosphate + NADH.
Cofactor Potassium (By similarity).
Enzyme regulation Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH (By similarity).
Pathway Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP; step 1/1.
Subunit Homotetramer (By similarity).
Similarity Belongs to the IMPDH/GMPR family.

Keywords [?]


Gene Ontology [?]

GO:0003938; Molecular function: IMP dehydrogenase activity.
GO:0046872; Molecular function: metal ion binding.
GO:0000166; Molecular function: nucleotide binding.
GO:0006177; Biological process: GMP biosynthetic process.

Cross-references [?]

PROSITE PS51371; CBS; 0-2; trigger=PRU00703;
PS00487; IMP_DH_GMP_RED; 1;
Pfam PF00571; CBS; 2;
PF00478; IMPDH; 1;
TIGRFAMs TIGR01302; IMP_dehydrog; 1;
PIRSF PIRSF000130; IMPDH; 1;

Features [?]

From: IMDH_TRIFO (P50097)
Key     From     To       Description   Tag   Condition   FTGroup
NP_BIND (Optional)     261     263       NAD (By similarity)     D-S-S  
case not <FT:1=D-S-S>
BINDING (Optional)     261     261       NAD (By similarity)     D  
end case
NP_BIND     312     314       NAD (By similarity)     G-x-G  
REGION     358     360       IMP binding (By similarity)     D-G-G  
REGION     381     382       IMP binding (By similarity)     G-x  
REGION     405     409       IMP binding (By similarity)     [YI]-x-x-x-[GA]  
ACT_SITE     319     319       Thioimidate intermediate (By similarity)     C  
METAL     314     314       Potassium; via carbonyl oxygen (By similarity)     G  
METAL     316     316       Potassium; via carbonyl oxygen (By similarity)     G  
METAL     319     319       Potassium; via carbonyl oxygen (By similarity)     C  
METAL (Optional)     485     485       Potassium; via carbonyl oxygen; shared with tetrameric partner (By similarity)     E  
METAL (Optional)     486     486       Potassium; via carbonyl oxygen; shared with tetrameric partner (By similarity)     [GS]  
METAL (Optional)     487     487       Potassium; via carbonyl oxygen; shared with tetrameric partner (By similarity)     [GH]  
BINDING     317     317       IMP (By similarity)     S  
BINDING     431     431       IMP (By similarity)     [EQ]  

Additional information [?]

Size range 400-554 amino acids
Related rules None
Templates P50097 (IMDH_TRIFO); P0C0H6 (IMDH_STRPY); P49058 (IMDH_BORBU); P0ADG7 (IMDH_ECOLI): [Recover all]
Fusion None