Annotation rule MF_01966
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General rule information [?]

Accession MF_01966
Dates 14-FEB-2012 (Created)
25-NOV-2013 (Last updated, Version 5)
Name NADHX_epimerase
Scope Bacteria
Archaea
case <OC:Bacteria> or <OC:Archaea>
end case


Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
NNRE
Protein name
RecName: Full=NAD(P)H-hydrate epimerase;
EC=5.1.99.6;
AltName: Full=NAD(P)HX epimerase;
Gene name
nnrE

Comments [?]

Function Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX (By similarity).
Catalytic activity (6R)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide = (6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide.
(6R)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide phosphate = (6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide phosphate.
Cofactor Binds 1 potassium ion per subunit (By similarity).
Similarity Belongs to the NnrE/AIBP family.

Keywords [?]


Gene Ontology [?]

GO:0052856; Molecular function: NADHX epimerase activity.

Cross-references [?]

PROSITE PS51385; YJEF_N; 1; trigger=PRU00719;
Pfam PF03853; YjeF_N; 1;
TIGRFAMs TIGR00197; YjeF_nterm; 1;

Features [?]

From: NNR_THEMA (Q9X024)
Key     From     To       Description   Tag   Condition   FTGroup
REGION     51     55       NAD(P)HX (By similarity)     x-N-G-x(2)  
REGION     118     124       NAD(P)HX (By similarity)        
METAL     52     52       Potassium (By similarity)     N  
METAL     114     114       Potassium (By similarity)     D  
METAL     150     150       Potassium (By similarity)     [ST]  
BINDING (Optional)     129     129       NAD(P)HX (By similarity)     Y  
BINDING     147     147       NAD(P)HX (By similarity)     [DE]  

Additional information [?]

Size range 204-288 amino acids
Related rules None
Templates Q9X024 (NNR_THEMA); P31806 (NNR_ECOLI): [Recover all]
Fusion Nter: None; Cter: MF_01965 (nnrD)