HAMAP rule MF_01988
General rule information
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| Accession | MF_01988 |
| Dates | 20-OCT-2016 (Created)
1-JUN-2023 (Last updated, Version 9) |
| Name | Succ_CoA_alpha |
| Scope(s) |
Bacteria Archaea |
| Template(s) | P0AGE9 (SUCD_ECOLI); P09143 (SUCD_THETH); O19069 (SUCA_PIG); [ Recover all ] |
| Triggered by |
case c? <OC:Bacteria> or <OC:Archaea>
HAMAP; MF_01988 (Get profile general information and statistics) end case
|
Propagated annotation
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Identifier, protein and gene names
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| Identifier | SUCD |
| Protein name | RecName: Full=Succinate--CoA ligase [ADP-forming] subunit alpha; EC=6.2.1.5; AltName: Full=Succinyl-CoA synthetase subunit alpha; Short=SCS-alpha; |
| Gene name | Name=sucD; |
Comments
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| FUNCTION | Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. |
| CATALYTIC ACTIVITY | Reaction=ATP + CoA + succinate = ADP + phosphate + succinyl-CoA; Xref=Rhea:RHEA:17661, ChEBI:CHEBI:30031, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57287, ChEBI:CHEBI:57292, ChEBI:CHEBI:456216; EC=6.2.1.5; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:17663; |
| CATALYTIC ACTIVITY | Reaction=CoA + GTP + succinate = GDP + phosphate + succinyl-CoA; Xref=Rhea:RHEA:22120, ChEBI:CHEBI:30031, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:57287, ChEBI:CHEBI:57292, ChEBI:CHEBI:58189; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:22122; |
| PATHWAY | Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1. |
| SUBUNIT | Heterotetramer of two alpha and two beta subunits. |
| SIMILARITY | Belongs to the succinate/malate CoA ligase alpha subunit family. |
Keywords
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Gene Ontology
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| GO:0004775; Molecular function:succinate-CoA ligase (ADP-forming) activity |
| GO:0006099; Biological process:tricarboxylic acid cycle |
Cross-references
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| PROSITE | PS01216; SUCCINYL_COA_LIG_1; 1; |
| PROSITE | PS00399; SUCCINYL_COA_LIG_2; 1; |
| Pfam | PF02629; CoA_binding; 1; |
| Pfam | PF00549; Ligase_CoA; 1; |
| Pfam | PF13607; Succ_CoA_lig; 1; |
| PRINTS | PR01798; SCOASYNTHASE; 1; |
| NCBIfam | TIGR01019; sucCoAalpha; 1; |
| PIRSF | PIRSF001553; SucCS_alpha; 1; |
Features
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| From: SUCD_ECOLI (P0AGE9) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 17 | 20 | /ligand="CoA" /ligand_id="ChEBI:CHEBI:57287" |
T-G-x(2) | ||||||||
| BINDING | 96 | 98 | /ligand="CoA" /ligand_id="ChEBI:CHEBI:57287" |
[IVL]-T-[ED] | ||||||||
| ACT_SITE | 247 | 247 | /note="Tele-phosphohistidine intermediate" | H | ||||||||
| BINDING | 43 | 43 | /ligand="CoA" /ligand_id="ChEBI:CHEBI:57287" |
K | ||||||||
| BINDING | 159 | 159 | /ligand="substrate" /ligand_note="ligand shared with subunit beta" |
Y | ||||||||
Additional information
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| Size range | 259-308 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |