HAMAP

Accession	MF_02006
Dates	24-APR-2006 (Created) 21-NOV-2011 (Last updated, Version 17)

Data class

Protein

Predictors

HAMAP; MF_02006; [distribution of match scores in UniProtKB];[seed alignment for MF_02006]

Names

Tyr_tRNA_synth_type1

Identifier

SYY

Protein name

RecName: Full=Tyrosine--tRNA ligase; EC=6.1.1.1; AltName: Full=Tyrosyl-tRNA synthetase; Short=TyrRS;

Gene name

tyrS

FUNCTION: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity).

CATALYTIC ACTIVITY: ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + L-tyrosyl-tRNA(Tyr).

SUBUNIT: Homodimer (By similarity).

SUBCELLULAR LOCATION: Cytoplasm (By similarity).

SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.

SIMILARITY: Contains 1 S4 RNA-binding domain.

PROSITE	PS00178; AA_TRNA_LIGASE_I; 1; PS50889; S4; 1; trigger=PRU00182;
Pfam	PF01479; S4; 1; PF00579; tRNA-synt_1b; 1;
PRINTS	PR01040; TRNASYNTHTYR; 1;
TIGRFAMs	TIGR00234; TyrS; 1;

Acetylation.

Aminoacyl-tRNA synthetase, ATP-binding, Cytoplasm, Ligase, Nucleotide-binding, Protein biosynthesis.

GO:0004831; Molecular function: tyrosine-tRNA ligase activity.
GO:0005524; Molecular function: ATP binding.
GO:0006437; Biological process: tyrosyl-tRNA aminoacylation.
GO:0005737; Cellular component: cytoplasm.

From: SYY_ECOLI (P0AGJ9)
Key		From		To		Description		Condition		FTGroup
MOTIF		42		51		"HIGH" region		[PCATI]-[TS]-[AGES]-x-[SA]-[LMI]-[HT]-[ILVA]-G-[HNSG]
MOTIF		235		239		"KMSKS" region		K-[FMILY]-G-K-[ST]
BINDING		37		37		Tyrosine (By similarity)		Y
BINDING		175		175		Tyrosine (By similarity)		Y
BINDING		179		179		Tyrosine (By similarity)		Q
BINDING		238		238		ATP (By similarity)		K

Key		From		To		Description		Condition		FTGroup
MOD_RES		144		144		N6-acetyllysine (By similarity)		K

Size range:	391-471 amino acids
Related UniRules:	MF_02007 (SYY); MF_02008 (SYY)
Template:	P0AGJ9 (SYY_ECOLI); P00952 (SYY_GEOSE); P41256 (SYY_THIFE); Q57834 (SYY_METJA): [Recover all]
Scope:	Bacteria
Fusion:	Nter: None; Cter: None
Duplicate:	in BACAN, BACC1, BACCR, BACCZ, BACHK, ENTFA, STRT1, STRT2
Plasmid encoded:	None
Comments:	Some species have a second copy of TyrRS in another subfamily (MF_02007). Shorter sequences in second copy of STRT1 and STRT2; sequences not included in alignment and not taken into account in size range.