HAMAP

Accession	MF_02008
Dates	30-MAY-2006 (Created) 2-DEC-2011 (Last updated, Version 9)

Data class

Protein

Predictors

HAMAP; MF_02008; [distribution of match scores in UniProtKB];[seed alignment for MF_02008]

Names

Tyr_tRNA_synth_type3

Identifier

SYY

Protein name

RecName: Full=Tyrosine--tRNA ligase; EC=6.1.1.1; AltName: Full=Tyrosyl-tRNA synthetase; Short=TyrRS;

Gene name

tyrS

FUNCTION: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity).

CATALYTIC ACTIVITY: ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + L-tyrosyl-tRNA(Tyr).

SUBUNIT: Homodimer (By similarity).

SUBCELLULAR LOCATION: Cytoplasm (By similarity).

SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 3 subfamily.

PROSITE	PS00178; AA_TRNA_LIGASE_I; 1;
Pfam	PF00579; tRNA-synt_1b; 1;
PRINTS	PR01040; TRNASYNTHTYR; 1;
TIGRFAMs	TIGR00234; TyrS; 1;

Cytoplasm, Aminoacyl-tRNA synthetase, ATP-binding, Ligase, Nucleotide-binding, Protein biosynthesis.

GO:0004831; Molecular function: tyrosine-tRNA ligase activity.
GO:0005524; Molecular function: ATP binding.
GO:0006437; Biological process: tyrosyl-tRNA aminoacylation.
GO:0005737; Cellular component: cytoplasm.

From: SYY_METJA (Q57834)
Key		From		To		Description		Condition		FTGroup
MOTIF		37		45		"HIGH" region		P-[ST]-G-[KERV]-[IVML]-H-[LMI]-G-H
MOTIF		204		208		"KMSKS" region		K-M-[SA]-S-S
BINDING		32		32		Tyrosine (By similarity)		Y
BINDING		151		151		Tyrosine (By similarity)		Y
BINDING		155		155		Tyrosine (By similarity)		Q
BINDING		158		158		Tyrosine (By similarity)		D
BINDING		173		173		Tyrosine (By similarity)		Q

Key		From		To		Description		Condition		FTGroup
BINDING		207		207		ATP (Potential)		S

Size range:	306-346 amino acids
Related UniRules:	MF_02006 (SYY); MF_02007 (SYY); MF_02009 (SYY)
Template:	P0AGJ9 (SYY_ECOLI); P00952 (SYY_GEOSE); P41256 (SYY_THIFE); Q57834 (SYY_METJA); O29482 (SYY_ARCFU); Q9YA64 (SYY_AERPE); O58739 (SYY_PYRHO): [Recover all]
Scope:	Archaea; Euryarchaeota
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None