HAMAP rule MF_02027
General rule information
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Accession | MF_02027 |
Dates | 22-APR-2015 (Created)
1-JUN-2023 (Last updated, Version 9) |
Name | WecD_RffC |
Scope(s) |
Bacteria Enterobacterales |
Template(s) | Q8FBQ3 (WECD_ECOL6); [ Recover all ] |
Triggered by |
HAMAP; MF_02027 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | WECD |
Protein name | RecName: Full=dTDP-fucosamine acetyltransferase; EC=2.3.1.210; AltName: Full=TDP-fucosamine acetyltransferase; AltName: Full=dTDP-4-amino-4,6-dideoxy-D-galactose acyltransferase; |
Gene name | Name=wecD; |
Comments
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FUNCTION | Catalyzes the acetylation of dTDP-fucosamine (dTDP-4-amino- 4,6-dideoxy-D-galactose) to dTDP-Fuc4NAc, which is utilized in the biosynthesis of the enterobacterial common antigen (ECA). |
CATALYTIC ACTIVITY | Reaction=acetyl-CoA + dTDP-4-amino-4,6-dideoxy-alpha-D-galactose = CoA + dTDP-4-acetamido-4,6-dideoxy-alpha-D-galactose + H(+); Xref=Rhea:RHEA:34443, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:68492, ChEBI:CHEBI:68493; EC=2.3.1.210; |
PATHWAY | Bacterial outer membrane biogenesis; enterobacterial common antigen biosynthesis. |
SUBUNIT | Homodimer. |
SIMILARITY | Belongs to the WecD family. |
Keywords
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Gene Ontology
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GO:0016747; Molecular function:acyltransferase activity, transferring groups other than amino-acyl groups |
GO:0009246; Biological process:enterobacterial common antigen biosynthetic process |
Cross-references
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Features
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From: WECD_ECOL6 (Q8FBQ3) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 168 | 174 | /ligand="acetyl-CoA" /ligand_id="ChEBI:CHEBI:57288" |
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ACT_SITE | 208 | 208 | /note="Proton donor" | Y | ||||||||
BINDING | 201 | 201 | /ligand="acetyl-CoA" /ligand_id="ChEBI:CHEBI:57288" |
N | ||||||||
BINDING | 207 | 207 | /ligand="acetyl-CoA" /ligand_id="ChEBI:CHEBI:57288" |
R |
Additional information
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Size range | 180-260 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |