HAMAP rule MF_02032
General rule information
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Accession | MF_02032 |
Dates | 26-MAY-2015 (Created)
1-JUN-2023 (Last updated, Version 7) |
Name | Tartronate_sem_reduc |
Scope(s) |
Bacteria Gammaproteobacteria |
Template(s) | P0ABQ2 (GARR_ECOLI); [ Recover all ] |
Triggered by |
HAMAP; MF_02032 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | GARR |
Protein name | RecName: Full=2-hydroxy-3-oxopropionate reductase; EC=1.1.1.60; AltName: Full=Tartronate semialdehyde reductase; Short=TSAR; |
Gene name | Name=garR; |
Comments
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FUNCTION | Catalyzes the reduction of tatronate semialdehyde to D- glycerate. |
CATALYTIC ACTIVITY | Reaction=(R)-glycerate + NADP(+) = 2-hydroxy-3-oxopropanoate + H(+) + NADPH; Xref=Rhea:RHEA:18841, ChEBI:CHEBI:15378, ChEBI:CHEBI:16659, ChEBI:CHEBI:57783, ChEBI:CHEBI:57978, ChEBI:CHEBI:58349; EC=1.1.1.60; |
CATALYTIC ACTIVITY | Reaction=(R)-glycerate + NAD(+) = 2-hydroxy-3-oxopropanoate + H(+) + NADH; Xref=Rhea:RHEA:18845, ChEBI:CHEBI:15378, ChEBI:CHEBI:16659, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:57978; EC=1.1.1.60; |
PATHWAY | Carbohydrate acid metabolism; galactarate degradation; D- glycerate from galactarate: step 3/3. |
SIMILARITY | Belongs to the HIBADH-related family. 2-hydroxy-3- oxopropionate reductase subfamily. |
Keywords
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Gene Ontology
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GO:0008679; Molecular function:2-hydroxy-3-oxopropionate reductase activity |
GO:0046392; Biological process:galactarate catabolic process |
Cross-references
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PROSITE | PS00895; 3_HYDROXYISOBUT_DH; 1; |
Pfam | PF14833; NAD_binding_11; 1; |
Pfam | PF03446; NAD_binding_2; 1; |
NCBIfam | TIGR01505; tartro_sem_red; 1; |
PIRSF | PIRSF000103; HIBADH; 1; |
Features
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From: GARR_ECOLI (P0ABQ2) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 4 | 18 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
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ACT_SITE | 170 | 170 | K | |||||||||
BINDING | 95 | 95 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
S | ||||||||
BINDING | 238 | 238 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
K |
Additional information
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Size range | 276-302 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |