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HAMAP rule MF_02040
General rule information
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Accession | MF_02040 |
Dates | 17-JUL-2015 (Created)
19-NOV-2022 (Last updated, Version 7) |
Name | Mrp_NBP35 |
Scope(s) |
Bacteria Archaea |
Template(s) | Q8ZNN5 (APBC_SALTY); Q6LZC5 (APBC_METMP); [ Recover all ] |
Triggered by |
case c? <OC:Bacteria> or <OC:Archaea>
HAMAP; MF_02040 (Get profile general information and statistics) end case
|
Propagated annotation
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Identifier, protein and gene names
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Identifier | APBC |
Protein name | RecName: Full=Iron-sulfur cluster carrier protein; |
Comments
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FUNCTION | Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP. |
SUBUNIT | Homodimer. |
SIMILARITY | Belongs to the Mrp/NBP35 ATP-binding proteins family. |
Keywords
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Gene Ontology
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GO:0005524; Molecular function:ATP binding |
GO:0016887; Molecular function:ATP hydrolysis activity |
GO:0051536; Molecular function:iron-sulfur cluster binding |
Cross-references
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Features
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From: APBC_SALTY (Q8ZNN5) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 115 | 122 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
[GA]-K-G-G-V-G-K-[ST] |
Additional information
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Size range | 235-460 amino acids |
Related rules |
MF_03038 MF_03039 |
Fusion | Nter: None Cter: None |
Comments | Profile MF_02040 includes all members of the Mrp/NBP35 family. Rule MF_02040 annotates bacterial and archaeal matches. See MF_03038 for eukaryotic NUBP1/NBP35 subfamily and MF_03039 for eukaryotic NUBP2/CFD1 subfamily. The CXXC motif is thought to be required for Fe-S cluster binding. However, the individual cysteine residues in the CXXC motif seem dispensable (see APBC_SACS2). Other members lack this characteristic CXXC motif in the C terminus. More studies will be required to determine which residues are ligands for the Fe-S cluster in bacteria and archaea. |