HAMAP rule MF_02051

General rule information [?]

Accession	MF_02051
Dates	7-JAN-2016 (Created) 5-MAY-2020 (Last updated, Version 5)
Name	LsrG
Scope(s)	Bacteria Enterobacterales
Template(s)	P64461 (LSRG_ECOLI); [ Recover all ]
Triggered by	HAMAP; MF_02051 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	LSRG
Protein name	RecName: Full=(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase; EC=5.3.1.32; AltName: Full=Autoinducer 2-degrading protein LsrG; Short=AI-2-degrading protein LsrG; AltName: Full=Phospho-(S)-4,5-dihydroxy-2,3-pentanedione isomerase; AltName: Full=Phospho-AI-2 isomerase;
Gene name	Name=lsrG;

Comments [?]

FUNCTION	Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the conversion of (4S)-4-hydroxy-5- phosphonooxypentane-2,3-dione (P-DPD) to 3-hydroxy-5- phosphonooxypentane-2,4-dione (P-HPD).
CATALYTIC ACTIVITY	Reaction=(2S)-2-hydroxy-3,4-dioxopentyl phosphate = 3-hydroxy-2,4- dioxopentyl phosphate; Xref=Rhea:RHEA:44360, ChEBI:CHEBI:71677, ChEBI:CHEBI:84359; EC=5.3.1.32;
SUBUNIT	Homodimer.
SUBCELLULAR LOCATION	Cytoplasm.
SIMILARITY	Belongs to the LsrG family.

Keywords [?]

Gene Ontology [?]

GO:0016861; Molecular function:intramolecular oxidoreductase activity, interconverting aldoses and ketoses

GO:0005737; Cellular component:cytoplasm

Cross-references [?]

PROSITE	PS51725; ABM; 1;
Pfam	PF03992; ABM; 1;

Features [?]

Additional information [?]