HAMAP rule MF_02058

General rule information [?]

Accession	MF_02058
Dates	11-MAR-2016 (Created) 1-JUN-2023 (Last updated, Version 8)
Name	Choline_CutC
Scope(s)	Bacteria Coriobacteriales Bacillota Pseudomonadota
Template(s)	Q30W70 (CUTC_OLEA2); [ Recover all ]
Triggered by	HAMAP; MF_02058 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	CUTC
Protein name	RecName: Full=Choline trimethylamine-lyase; Short=Choline TMA-lyase; EC=4.3.99.4; AltName: Full=Choline utilization protein C;
Gene name	Name=cutC;

Comments [?]

FUNCTION	Glycine radical enzyme that catalyzes the cleavage of a C-N bond in choline, producing trimethylamine (TMA) and acetaldehyde.
CATALYTIC ACTIVITY	Reaction=choline = acetaldehyde + trimethylamine; Xref=Rhea:RHEA:35095, ChEBI:CHEBI:15343, ChEBI:CHEBI:15354, ChEBI:CHEBI:58389; EC=4.3.99.4;
PATHWAY	Amine and polyamine metabolism; choline degradation.
PTM	Requires the activating protein CutD to generate the key active site glycyl radical on #{Gly-821} that is involved in catalysis.
SIMILARITY	Belongs to the glycyl radical enzyme (GRE) family. CutC subfamily.

Keywords [?]

Gene Ontology [?]

GO:0016840; Molecular function:carbon-nitrogen lyase activity

GO:0042426; Biological process:choline catabolic process

Cross-references [?]

Features [?]

From: CUTC_OLEA2 (Q30W70)

Key

From

Description

Tag

Condition

FTGroup

ACT_SITE

489

/note="Cysteine radical intermediate"

ACT_SITE

491

/note="Proton acceptor"

MOD_RES

821

/note="Glycine radical"

Additional information [?]