HAMAP rule MF_02076

General rule information [?]

Accession	MF_02076
Dates	10-NOV-2016 (Created) 1-JUN-2023 (Last updated, Version 5)
Name	Glu_tRNA_synth_type2
Scope(s)	Archaea
Template(s)	P04805 (SYE_ECOLI); O25360 (SYE2_HELPY); P27000 (SYE_THET8); Q8DLI5 (SYE_THEVB); [ Recover all ]
Triggered by	HAMAP; MF_02076 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	SYE
Protein name	RecName: Full=Glutamate--tRNA ligase; EC=6.1.1.17; AltName: Full=Glutamyl-tRNA synthetase; Short=GluRS;
Gene name	Name=gltX;

Comments [?]

FUNCTION	Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
CATALYTIC ACTIVITY	Reaction=ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L- glutamyl-tRNA(Glu); Xref=Rhea:RHEA:23540, Rhea:RHEA-COMP:9663, Rhea:RHEA-COMP:9680, ChEBI:CHEBI:29985, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:78442, ChEBI:CHEBI:78520, ChEBI:CHEBI:456215; EC=6.1.1.17;
SUBCELLULAR LOCATION	Cytoplasm.
SIMILARITY	Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.

Keywords [?]

Gene Ontology [?]

GO:0005524; Molecular function:ATP binding

GO:0004818; Molecular function:glutamate-tRNA ligase activity

GO:0006424; Biological process:glutamyl-tRNA aminoacylation

GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Features [?]

From: SYE_METJA (Q58772)

Key

From

Description

Tag

Condition

FTGroup

MOTIF

108

/note="'HIGH' region"

P-[SNE]-P-x(4)-[HTS]-[LIVM]-G-x

Additional information [?]

Size range	530-640 amino acids
Related rules	MF_01428
Fusion	Nter: None Cter: None
Comments	This signature is specific for archaeal and eukaryotic cytoplasmic glutamate--tRNA ligases. See MF_00022 for bacterial and eukaryotic mitochondrial glutamate--tRNA ligases.