HAMAP rule MF_02079
General rule information
[?]
Accession | MF_02079 |
Dates | 23-NOV-2016 (Created)
1-JUN-2023 (Last updated, Version 9) |
Name | PGT_RodA |
Scope(s) |
Bacteria |
Template(s) | P0ABG7 (RODA_ECOLI); P39604 (RODA_BACSU); [ Recover all ] |
Triggered by |
HAMAP; MF_02079 (Get profile general information and statistics) |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
Identifier | RODA |
case <OC:Pseudomonadota> | |
Protein name | RecName: Full=Peptidoglycan glycosyltransferase MrdB; Short=PGT; EC=2.4.1.129; AltName: Full=Cell elongation protein RodA; AltName: Full=Cell wall polymerase; AltName: Full=Peptidoglycan polymerase; Short=PG polymerase; |
Gene name | Name=mrdB; Synonyms=rodA; |
else | |
Protein name | RecName: Full=Peptidoglycan glycosyltransferase RodA; Short=PGT; EC=2.4.1.129; AltName: Full=Cell elongation protein RodA; AltName: Full=Cell wall polymerase; AltName: Full=Peptidoglycan polymerase; Short=PG polymerase; |
Gene name | Name=rodA; |
end case |
Comments
[?]
FUNCTION | Peptidoglycan polymerase that is essential for cell wall elongation. |
CATALYTIC ACTIVITY | Reaction=[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D- Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc- (1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa- cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma- D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+); Xref=Rhea:RHEA:23708, Rhea:RHEA-COMP:9602, Rhea:RHEA-COMP:9603, ChEBI:CHEBI:15378, ChEBI:CHEBI:58405, ChEBI:CHEBI:60033, ChEBI:CHEBI:78435; EC=2.4.1.129; |
PATHWAY | Cell wall biogenesis; peptidoglycan biosynthesis. |
case <OC:Pseudomonadota> or (defined <Property:Membrane> and <Property:Membrane=2>) | |
SUBCELLULAR LOCATION | Cell inner membrane; Multi-pass membrane protein. |
else | |
SUBCELLULAR LOCATION | Cell membrane; Multi-pass membrane protein. |
end case | |
SIMILARITY | Belongs to the SEDS family. MrdB/RodA subfamily. |
Keywords
[?]
case <OC:Pseudomonadota> or (defined <Property:Membrane> and <Property:Membrane=2>) | |
Cell inner membrane | |
end case | |
Cell membrane | |
Cell shape | |
Cell wall biogenesis/degradation | |
Glycosyltransferase | |
Membrane | |
Peptidoglycan synthesis | |
Transferase | |
Transmembrane | |
Transmembrane helix |
Gene Ontology
[?]
GO:0008955; Molecular function:peptidoglycan glycosyltransferase activity |
GO:0009252; Biological process:peptidoglycan biosynthetic process |
GO:0005886; Cellular component:plasma membrane |
Cross-references
[?]
PROSITE | PS00428; FTSW_RODA_SPOVE; 1; |
Pfam | PF01098; FTSW_RODA_SPOVE; 1; |
NCBIfam | TIGR02210; rodA_shape; 1; |
General | Transmembrane; -; 7-12; |
Features
[?]
Additional information
[?]
Size range | 310-470 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |