HAMAP rule MF_02080

General rule information [?]

Accession	MF_02080
Dates	1-DEC-2016 (Created) 26-JAN-2023 (Last updated, Version 8)
Name	FtsI_transpept
Scope(s)	Bacteria Pseudomonadota
Template(s)	P0AD68 (FTSI_ECOLI); P08149 (PBP2_NEIGO); [ Recover all ]
Triggered by	HAMAP; MF_02080 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

case not <OC:Neisseria>
Identifier	FTSI
Protein name	RecName: Full=Peptidoglycan D,D-transpeptidase FtsI; EC=3.4.16.4; AltName: Full=Penicillin-binding protein 3; Short=PBP-3;
Gene name	Name=ftsI;
else case <OC:Neisseria>
Identifier	PBP2
Protein name	RecName: Full=Probable peptidoglycan D,D-transpeptidase PenA; EC=3.4.16.4; AltName: Full=Penicillin-binding protein 2; Short=PBP-2;
Gene name	Name=penA;
end case

Comments [?]

FUNCTION	Catalyzes cross-linking of the peptidoglycan cell wall at the division septum.
CATALYTIC ACTIVITY	Reaction=Preferential cleavage: (Ac)2-L-Lys-D-Ala-\|-D-Ala. Also transpeptidation of peptidyl-alanyl moieties that are N-acyl substituents of D-alanine.; EC=3.4.16.4;
PATHWAY	Cell wall biogenesis; peptidoglycan biosynthesis.
case <Feature:Transmembrane==1>
SUBCELLULAR LOCATION	Cell inner membrane; Single-pass membrane protein.
end case
SIMILARITY	Belongs to the transpeptidase family. FtsI subfamily.

Keywords [?]

Gene Ontology [?]

GO:0009002; Molecular function:serine-type D-Ala-D-Ala carboxypeptidase activity

GO:0043093; Biological process:FtsZ-dependent cytokinesis

GO:0009252; Biological process:peptidoglycan biosynthetic process

GO:0005886; Cellular component:plasma membrane

Cross-references [?]

Features [?]

From: FTSI_ECOLI (P0AD68)

Key

From

Description

Tag

Condition

FTGroup

ACT_SITE

307

/note="Acyl-ester intermediate"

Additional information [?]

Size range	520-690 amino acids
Related rules	None
Fusion	Nter: None Cter: None
Comments	Second copy in Pseudomonas aeruginosa (penicillin-binding protein 3 homolog), which has probably the same catalytic activity. Does not match FTSI_CAUVN, which seems divergent.