HAMAP rule MF_02082
General rule information
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| Accession | MF_02082 |
| Dates | 13-DEC-2016 (Created)
1-JUN-2023 (Last updated, Version 14) |
| Name | LysZ |
| Scope(s) |
Bacteria Archaea |
| Template(s) | Q4JAQ2 (LYSZ_SULAC); Q980X0 (LYSZ_SACS2); O50147 (LYSZ_THET2); [ Recover all ] |
| Triggered by |
HAMAP; MF_02082 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | LYSZ |
| case <OC:Sulfolobales> | |
| Protein name | RecName: Full=[LysW]-aminoadipate/[LysW]-glutamate kinase; EC=2.7.2.17; EC=2.7.2.19; |
| else case <OC:Archaea> and not <OC:Sulfolobales> | |
| Protein name | RecName: Full=Putative [LysW]-aminoadipate/[LysW]-glutamate kinase; EC=2.7.2.17; EC=2.7.2.19; |
| else case <OC:Deinococcota> | |
| Protein name | RecName: Full=[LysW]-aminoadipate kinase; EC=2.7.2.17; |
| else case <OC:Bacteria> and not <OC:Deinococcota> | |
| Protein name | RecName: Full=Putative [LysW]-aminoadipate kinase; EC=2.7.2.17; |
| end case | |
| Gene name | Name=lysZ; |
Comments
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| case <OC:Archaea> | |
| FUNCTION | Involved in both the arginine and lysine biosynthetic pathways. Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis). |
| else case <OC:Bacteria> | |
| FUNCTION | Catalyzes the phosphorylation of LysW-gamma-alpha- aminoadipate. |
| end case | |
| CATALYTIC ACTIVITY | Reaction=[amino-group carrier protein]-C-terminal-N-(1,4- dicarboxybutan-1-yl)-L-glutamine + ATP = [amino-group carrier protein]-C-terminal-N-(1-carboxy-5-phosphooxy-5-oxopentan-1-yl)-L- glutamine + ADP; Xref=Rhea:RHEA:41944, Rhea:RHEA-COMP:9694, Rhea:RHEA-COMP:9712, ChEBI:CHEBI:30616, ChEBI:CHEBI:78499, ChEBI:CHEBI:78503, ChEBI:CHEBI:456216; EC=2.7.2.17; |
| case <OC:Archaea> | |
| CATALYTIC ACTIVITY | Reaction=[amino-group carrier protein]-C-terminal-gamma-(L-glutamyl)-L- glutamate + ATP = [amino-group carrier protein]-C-terminal-gamma-(5- phospho-L-glutamyl)-L-glutamate + ADP; Xref=Rhea:RHEA:52632, Rhea:RHEA-COMP:13311, Rhea:RHEA-COMP:13313, ChEBI:CHEBI:30616, ChEBI:CHEBI:136714, ChEBI:CHEBI:136717, ChEBI:CHEBI:456216; EC=2.7.2.19; |
| end case | |
| PATHWAY | Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (Thermus route): step 2/5. |
| case <OC:Archaea> | |
| PATHWAY | Amino-acid biosynthesis; L-arginine biosynthesis. |
| end case | |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the acetylglutamate kinase family. LysZ subfamily. |
Keywords
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| Amino-acid biosynthesis | |
| case <OC:Archaea> | |
| Arginine biosynthesis | |
| end case | |
| ATP-binding | |
| Cytoplasm | |
| Kinase | |
| Lysine biosynthesis | |
| Nucleotide-binding | |
| Transferase | |
Gene Ontology
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| GO:0016301; Molecular function:kinase activity | |
| case <OCellular component:Archaea> | |
| GO:0042450; Biological process:arginine biosynthetic process via ornithine | |
| end case | |
| GO:0019878; Biological process:lysine biosynthetic process via aminoadipic acid | |
| GO:0005737; Cellular component:cytoplasm | |
Cross-references
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| Pfam | PF00696; AA_kinase; 1; |
| PRINTS | PR00474; GLU5KINASE; 1; |
| NCBIfam | TIGR00761; argB; 1; |
| PIRSF | PIRSF000728; NAGK; 1; |
Features
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| From: LYSZ_SULAC (Q4JAQ2) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 35 | 36 | /ligand="substrate" | G-G | ||||||||
| BINDING | 62 | 62 | /ligand="substrate" | R | ||||||||
| BINDING | 166 | 166 | /ligand="substrate" | N | ||||||||
| SITE | 5 | 5 | /note="Transition state stabilizer" | K | ||||||||
| SITE | 223 | 223 | /note="Transition state stabilizer" | K | ||||||||
Additional information
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| Size range | 240-330 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |