HAMAP

Accession	MF_02114
Dates	6-AUG-2010 (Created) 29-SEP-2011 (Last updated, Version 3)

Name

CofC

Scope

Bacteria; Actinobacteria Bacteria; Chloroflexi Bacteria; Proteobacteria Bacteria; Thermobaculum Archaea

Triggered by

HAMAP; MF_02114 (Get profile general information and statistics)

Identifier

COFC

Protein name

RecName: Full=2-phospho-L-lactate guanylyltransferase; Short=LP guanylyltransferase; EC=2.7.7.68;

Gene name

cofC

FUNCTION	Guanylyltransferase that catalyzes the activation of 2-phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor (By similarity).
CATALYTIC ACTIVITY	(2S)-2-phospholactate + GTP = (2S)-lactyl-2-diphospho-5'-guanosine + diphosphate.
PATHWAY	Cofactor biosynthesis; coenzyme F420 biosynthesis.

SUBUNIT

Homodimer (By similarity).

SIMILARITY

Belongs to the CofC family.

GTP-binding
Nucleotide-binding
Nucleotidyltransferase
Transferase

GO:0043814; Molecular function: phospholactate guanylyltransferase activity.
GO:0009108; Biological process: coenzyme biosynthetic process.

Pfam	PF01983; CofC; 1;
TIGRFAMs	TIGR03552; F420_cofC; 1;

Size range:	190-316 amino acids
Related Rules:	None
Templates:	Q58297 (COFC_METJA); A0QUZ4 (COFC_MYCS2); Q8PU52 (COFC_METMA): [Recover all]
Fusion:	None

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