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Annotation rule MF_02114
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General rule information [?]

Accession MF_02114
Dates 6-AUG-2010 (Created)
14-NOV-2014 (Last updated, Version 5)
Name CofC
Scope Bacteria; Actinobacteria
Bacteria; Chloroflexi
Bacteria; Proteobacteria
Bacteria; Thermobaculum
Archaea
Templates Q58297 (COFC_METJA); A0QUZ4 (COFC_MYCS2); Q8PU52 (COFC_METMA): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
COFC
Protein name
RecName: Full=2-phospho-L-lactate guanylyltransferase;
Short=LP guanylyltransferase;
EC=2.7.7.68;
Gene name
cofC

Comments [?]

Function Guanylyltransferase that catalyzes the activation of 2-phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.
Catalytic activity (2S)-2-phospholactate + GTP = (2S)-lactyl-2-diphospho-5'-guanosine + diphosphate.
Pathway Cofactor biosynthesis; coenzyme F420 biosynthesis.
case <OC:Archaea>
Subunit Homodimer.
end case
Similarity Belongs to the CofC family.

Keywords [?]


Gene Ontology [?]

GO:0043814; Molecular function: phospholactate guanylyltransferase activity.
GO:0009108; Biological process: coenzyme biosynthetic process.

Cross-references [?]

Pfam PF01983; CofC; 1;
TIGRFAMs TIGR03552; F420_cofC; 1;

Additional information [?]

Size range 190-316 amino acids
Related rules None
Fusion None