HAMAP rule MF_02114

General rule information [?]

Accession	MF_02114
Dates	6-AUG-2010 (Created) 1-JUN-2023 (Last updated, Version 17)
Name	CofC
Scope(s)	Bacteria Actinomycetota Chloroflexota Pseudomonadota Thermobaculum Archaea
Template(s)	P9WP83 (FBID_MYCTU); Q58297 (COFC_METJA); A0QUZ4 (FBID_MYCS2); Q8PU52 (COFC_METMA); E5ASS2 (FBID_MYCRK); [ Recover all ]
Triggered by	HAMAP; MF_02114 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

case <OC:Archaea>
Identifier	COFC
Protein name	RecName: Full=2-phospho-L-lactate guanylyltransferase; Short=LP guanylyltransferase; EC=2.7.7.68;
Gene name	Name=cofC;
else case <OC:Actinomycetota>
Identifier	FBID
Protein name	RecName: Full=Phosphoenolpyruvate guanylyltransferase; Short=PEP guanylyltransferase; EC=2.7.7.105;
Gene name	Name=fbiD;
else case <OC:Pseudomonadota>
Identifier	FBID
Protein name	RecName: Full=3-phospho-D-glycerate guanylyltransferase; Short=3PG guanylyltransferase; EC=2.7.7.106;
Gene name	Name=fbiD;
else
Identifier	FBID
Protein name	RecName: Full=Phosphoenolpyruvate guanylyltransferase; Short=PEP guanylyltransferase; EC=2.7.7.105;
Gene name	Name=fbiD;
end case

Comments [?]

case <OC:Archaea>
FUNCTION	Guanylyltransferase that catalyzes the activation of (2S)-2- phospholactate (2-PL) as (2S)-lactyl-2-diphospho-5'-guanosine, via the condensation of 2-PL with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.
else case <OC:Actinomycetota>
FUNCTION	Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.
else case <OC:Pseudomonadota>
FUNCTION	Guanylyltransferase that catalyzes the activation of (2R)-3- phosphoglycerate (3PG) as 3-[(R)-glyceryl]-diphospho-5'-guanosine, via the condensation of 3PG with GTP. It is involved in the biosynthesis of a derivative of the hydride carrier cofactor coenzyme F420, 3PG-F420.
else
FUNCTION	Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.
end case
case <OC:Archaea>
CATALYTIC ACTIVITY	Reaction=(2S)-2-phospholactate + GTP + H(+) = (2S)-lactyl-2-diphospho- 5'-guanosine + diphosphate; Xref=Rhea:RHEA:63424, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:59435, ChEBI:CHEBI:59906; EC=2.7.7.68;
else case <OC:Actinomycetota>
CATALYTIC ACTIVITY	Reaction=GTP + H(+) + phosphoenolpyruvate = diphosphate + enolpyruvoyl- 2-diphospho-5'-guanosine; Xref=Rhea:RHEA:30519, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:58702, ChEBI:CHEBI:143701; EC=2.7.7.105;
else case <OC:Pseudomonadota>
CATALYTIC ACTIVITY	Reaction=(2R)-3-phosphoglycerate + GTP + H(+) = 3-[(R)-glyceryl]- diphospho-5'-guanosine + diphosphate; Xref=Rhea:RHEA:63440, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:58272, ChEBI:CHEBI:147306; EC=2.7.7.106;
else
CATALYTIC ACTIVITY	Reaction=GTP + H(+) + phosphoenolpyruvate = diphosphate + enolpyruvoyl- 2-diphospho-5'-guanosine; Xref=Rhea:RHEA:30519, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:58702, ChEBI:CHEBI:143701; EC=2.7.7.105;
end case
PATHWAY	Cofactor biosynthesis; coenzyme F420 biosynthesis.
case <OC:Archaea>
SUBUNIT	Homodimer.
end case
SIMILARITY	Belongs to the CofC family.