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HAMAP rule MF_02120

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General rule information [?]

Accession MF_02120
Dates 10-JUN-2011 (Created)
1-JUN-2023 (Last updated, Version 12)
Name LysA
Scope(s) Bacteria
Archaea
Template(s) P9WIU7 (DCDA_MYCTU); P00861 (DCDA_ECOLI); E0IWI3 (DCDA_ECOLW); Q58497 (DCDA_METJA); B4XMC6 (DCDA_HELPX); Q5HG20 (DCDA_STAAC); O67262 (DCDA_AQUAE); Q9X1K5 (DCDA_THEMA); Q9KVL7 (DCDA_VIBCH); [ Recover all ]
Triggered by HAMAP; MF_02120 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier DCDA
Protein name RecName: Full=Diaminopimelate decarboxylase;
                 Short=DAP decarboxylase;
                 Short=DAPDC;
                 EC=4.1.1.20;
Gene name Name=lysA;

Comments [?]

FUNCTIONSpecifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine.
CATALYTIC ACTIVITY Reaction=H(+) + meso-2,6-diaminoheptanedioate = CO2 + L-lysine; Xref=Rhea:RHEA:15101, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:32551, ChEBI:CHEBI:57791; EC=4.1.1.20;
COFACTOR Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
PATHWAYAmino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; L-lysine from DL-2,6-diaminopimelate: step 1/1.
SUBUNITHomodimer.
SIMILARITYBelongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.

Keywords [?]


Gene Ontology [?]

GO:0008836; Molecular function:diaminopimelate decarboxylase activity
GO:0030170; Molecular function:pyridoxal phosphate binding
GO:0009089; Biological process:lysine biosynthetic process via diaminopimelate

Cross-references [?]

PROSITE PS00878; ODR_DC_2_1; 1;
PROSITE PS00879; ODR_DC_2_2; 1;
Pfam PF02784; Orn_Arg_deC_N; 1;
Pfam PF00278; Orn_DAP_Arg_deC; 1;
PRINTS PR01181; DAPDCRBXLASE; 1;
PRINTS PR01179; ODADCRBXLASE; 1;
NCBIfam TIGR01048; LysA; 1;

Features [?]

From: DCDA_MYCTU (P9WIU7)
Key From To Description Tag Condition FTGroup
BINDING 300 303 /ligand="pyridoxal 5'-phosphate"
/ligand_id="ChEBI:CHEBI:597326"
E-x-G-R
BINDING 258 258 /ligand="pyridoxal 5'-phosphate"
/ligand_id="ChEBI:CHEBI:597326"
G
BINDING 303 303 /ligand="substrate" R
BINDING 344 344 /ligand="substrate" R
BINDING 348 348 /ligand="substrate" Y
BINDING 376 376 /ligand="substrate" E
BINDING 405 405 /ligand="pyridoxal 5'-phosphate"
/ligand_id="ChEBI:CHEBI:597326"
Y
BINDING 405 405 /ligand="substrate" Y
MOD_RES 72 72 /note="N6-(pyridoxal phosphate)lysine" K

Additional information [?]

Size range 379-474 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments RHEA:15102;



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