HAMAP rule MF_02120
General rule information
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| Accession | MF_02120 |
| Dates | 10-JUN-2011 (Created)
1-JUN-2023 (Last updated, Version 12) |
| Name | LysA |
| Scope(s) |
Bacteria Archaea |
| Template(s) | P9WIU7 (DCDA_MYCTU); P00861 (DCDA_ECOLI); E0IWI3 (DCDA_ECOLW); Q58497 (DCDA_METJA); B4XMC6 (DCDA_HELPX); Q5HG20 (DCDA_STAAC); O67262 (DCDA_AQUAE); Q9X1K5 (DCDA_THEMA); Q9KVL7 (DCDA_VIBCH); [ Recover all ] |
| Triggered by |
HAMAP; MF_02120 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | DCDA |
| Protein name | RecName: Full=Diaminopimelate decarboxylase; Short=DAP decarboxylase; Short=DAPDC; EC=4.1.1.20; |
| Gene name | Name=lysA; |
Comments
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| FUNCTION | Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. |
| CATALYTIC ACTIVITY | Reaction=H(+) + meso-2,6-diaminoheptanedioate = CO2 + L-lysine; Xref=Rhea:RHEA:15101, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:32551, ChEBI:CHEBI:57791; EC=4.1.1.20; |
| COFACTOR | Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; |
| PATHWAY | Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; L-lysine from DL-2,6-diaminopimelate: step 1/1. |
| SUBUNIT | Homodimer. |
| SIMILARITY | Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily. |
Keywords
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Gene Ontology
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| GO:0008836; Molecular function:diaminopimelate decarboxylase activity |
| GO:0030170; Molecular function:pyridoxal phosphate binding |
| GO:0009089; Biological process:lysine biosynthetic process via diaminopimelate |
Cross-references
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| PROSITE | PS00878; ODR_DC_2_1; 1; |
| PROSITE | PS00879; ODR_DC_2_2; 1; |
| Pfam | PF02784; Orn_Arg_deC_N; 1; |
| Pfam | PF00278; Orn_DAP_Arg_deC; 1; |
| PRINTS | PR01181; DAPDCRBXLASE; 1; |
| PRINTS | PR01179; ODADCRBXLASE; 1; |
| NCBIfam | TIGR01048; LysA; 1; |
Features
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| From: DCDA_MYCTU (P9WIU7) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 300 | 303 | /ligand="pyridoxal 5'-phosphate" /ligand_id="ChEBI:CHEBI:597326" |
E-x-G-R | ||||||||
| BINDING | 258 | 258 | /ligand="pyridoxal 5'-phosphate" /ligand_id="ChEBI:CHEBI:597326" |
G | ||||||||
| BINDING | 303 | 303 | /ligand="substrate" | R | ||||||||
| BINDING | 344 | 344 | /ligand="substrate" | R | ||||||||
| BINDING | 348 | 348 | /ligand="substrate" | Y | ||||||||
| BINDING | 376 | 376 | /ligand="substrate" | E | ||||||||
| BINDING | 405 | 405 | /ligand="pyridoxal 5'-phosphate" /ligand_id="ChEBI:CHEBI:597326" |
Y | ||||||||
| BINDING | 405 | 405 | /ligand="substrate" | Y | ||||||||
| MOD_RES | 72 | 72 | /note="N6-(pyridoxal phosphate)lysine" | K | ||||||||
Additional information
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| Size range | 379-474 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | RHEA:15102; |