HAMAP rule MF_02227
General rule information
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| Accession | MF_02227 |
| Dates | 19-SEP-2019 (Created)
1-JUN-2023 (Last updated, Version 7) |
| Name | RPE |
| Scope(s) |
Archaea Bacteria |
| Template(s) | P0AG07 (RPE_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_02227 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | RPE |
| Protein name | RecName: Full=Ribulose-phosphate 3-epimerase; EC=5.1.3.1; |
| Gene name | Name=rpe; |
Comments
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| FUNCTION | Catalyzes the reversible epimerization of D-ribulose 5- phosphate to D-xylulose 5-phosphate. |
| CATALYTIC ACTIVITY | Reaction=D-ribulose 5-phosphate = D-xylulose 5-phosphate; Xref=Rhea:RHEA:13677, ChEBI:CHEBI:57737, ChEBI:CHEBI:58121; EC=5.1.3.1; |
| COFACTOR | Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240; Note=Binds 1 divalent metal cation per subunit.; |
| PATHWAY | Carbohydrate degradation. |
| SIMILARITY | Belongs to the ribulose-phosphate 3-epimerase family. |
Keywords
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Gene Ontology
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| GO:0046872; Molecular function:metal ion binding |
| GO:0004750; Molecular function:D-ribulose-phosphate 3-epimerase activity |
| GO:0019323; Biological process:pentose catabolic process |
Cross-references
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| PROSITE | PS01085; RIBUL_P_3_EPIMER_1; 1; |
| PROSITE | PS01086; RIBUL_P_3_EPIMER_2; 1; |
| Pfam | PF00834; Ribul_P_3_epim; 1; |
| NCBIfam | TIGR01163; rpe; 1; |
| PIRSF | PIRSF001461; RPE; 1; |
Features
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| From: RPE_ECOLI (P0AG07) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 144 | 147 | /ligand="substrate" | G-[FY]-x-G | ||||||||
| BINDING | 177 | 179 | /ligand="substrate" | D-G-G | ||||||||
| BINDING | 199 | 200 | /ligand="substrate" | [GA]-S | ||||||||
| ACT_SITE | 36 | 36 | /note="Proton acceptor" | D | ||||||||
| ACT_SITE | 177 | 177 | /note="Proton donor" | D | ||||||||
| BINDING | 34 | 34 | /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240" |
H | 1 | |||||||
| BINDING | 36 | 36 | /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240" |
D | 1 | |||||||
| BINDING | 68 | 68 | /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240" |
H | 1 | |||||||
| BINDING | 177 | 177 | /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240" |
D | 1 | |||||||
| BINDING | 9 | 9 | /ligand="substrate" | S | ||||||||
| BINDING | 68 | 68 | /ligand="substrate" | H | ||||||||
Additional information
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| Size range | 200-280 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |