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HAMAP rule MF_03002

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General rule information [?]

Accession MF_03002
Dates 29-JAN-2009 (Created)
20-NOV-2019 (Last updated, Version 15)
Name eIF3c
Scope(s) Eukaryota
Template(s) Q99613 (EIF3C_HUMAN); Q8R1B4 (EIF3C_MOUSE); Q6PFQ2 (EIF3C_DANRE); A1ZAX1 (EIF3C_DROME); O14164 (EIF3C_SCHPO); P32497 (EIF3C_YEAST); [ Recover all ]
Triggered by HAMAP; MF_03002 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier EIF3C
case <OC:Mammalia> or <OC:Viridiplantae>
Protein name RecName: Full=Eukaryotic translation initiation factor 3 subunit C;
                 Short=eIF3c;
AltName: Full=Eukaryotic translation initiation factor 3 subunit 8;
AltName: Full=eIF3 p110;
else case <OC:Fungi>
Protein name RecName: Full=Eukaryotic translation initiation factor 3 subunit C;
                 Short=eIF3c;
AltName: Full=Eukaryotic translation initiation factor 3 93 kDa subunit homolog;
                 Short=eIF3 p93;
AltName: Full=Translation initiation factor eIF3, p93 subunit homolog;
else
Protein name RecName: Full=Eukaryotic translation initiation factor 3 subunit C;
                 Short=eIF3c;
AltName: Full=Eukaryotic translation initiation factor 3 subunit 8;
end case
case <OC:Vertebrata>
Gene name Name=EIF3C; Synonyms=EIF3S8;
else case <OC:Caenorhabditis>
Gene name Name=eif-3.C;
else case <OC:Drosophilidae>
Gene name Name=eIF3c; Synonyms=eIF3-S8;
else case <OC:Fungi>
Gene name Name=NIP1;
end case

Comments [?]

case <OC:Mammalia>
FUNCTIONComponent of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
else
FUNCTIONComponent of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
end case
case <OC:Mammalia>
SUBUNITComponent of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.
else case <OC:Vertebrata> and not <OC:Mammalia>
SUBUNITComponent of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: @gn(EIF3A), @gn(EIF3B), @gn(EIF3C), @gn(EIF3D), @gn(EIF3E), @gn(EIF3F), @gn(EIF3G), @gn(EIF3H), @gn(EIF3I), @gn(EIF3J), @gn(EIF3K), @gn(EIF3L) and @gn(EIF3M).
else case <OC:Drosophilidae>
SUBUNITComponent of the eukaryotic translation initiation factor 3 (eIF-3) complex. The eIF-3 complex interacts with pix.
else
SUBUNITComponent of the eukaryotic translation initiation factor 3 (eIF-3) complex.
end case
SUBCELLULAR LOCATIONCytoplasm.
case <OC:Mammalia>
PTMPhosphorylated. Phosphorylation is enhanced upon serum stimulation.
end case
SIMILARITYBelongs to the eIF-3 subunit C family.

Keywords [?]

Cytoplasm
Initiation factor
Protein biosynthesis
case <OC:Mammalia>
Phosphoprotein
end case

Gene Ontology [?]

GO:0003743; Molecular function:translation initiation factor activity
GO:0001732; Biological process:formation of cytoplasmic translation initiation complex
GO:0002183; Biological process:cytoplasmic translational initiation
GO:0005737; Cellular component:cytoplasm
GO:0005852; Cellular component:eukaryotic translation initiation factor 3 complex
GO:0016282; Cellular component:eukaryotic 43S preinitiation complex
GO:0033290; Cellular component:eukaryotic 48S preinitiation complex

Cross-references [?]

Pfam PF05470; eIF-3c_N; 1;
Pfam PF01399; PCI; 1;
PROSITE PS50250; PCI; 1;

Features [?]

From: EIF3C_HUMAN (Q99613)
Key From To Description Tag Condition FTGroup
case <OC:Mammalia>
MOD_RES 9 9 /note="Phosphoserine" S
MOD_RES 11 11 /note="Phosphoserine" S
MOD_RES 13 13 /note="Phosphoserine" S
MOD_RES 15 15 /note="Phosphoserine" S
MOD_RES 16 16 /note="Phosphoserine" S
MOD_RES 18 18 /note="Phosphoserine" S
MOD_RES 39 39 /note="Phosphoserine" S
MOD_RES 166 166 /note="Phosphoserine" S
MOD_RES 524 524 /note="Phosphothreonine" T
MOD_RES 909 909 /note="Phosphoserine" S
end case

Additional information [?]

Size range 803-1042 amino acids
Related rules None
Fusion Nter: None Cter: None



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