HAMAP rule MF_03006
General rule information
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Accession | MF_03006 |
Dates | 29-JAN-2009 (Created)
20-NOV-2019 (Last updated, Version 13) |
Name | eIF3g |
Scope(s) |
Eukaryota |
Template(s) | O75821 (EIF3G_HUMAN); Q9Z1D1 (EIF3G_MOUSE); Q9W4X7 (EI3G1_DROME); P78795 (EIF3G_SCHPO); Q04067 (EIF3G_YEAST); [ Recover all ] |
Triggered by |
HAMAP; MF_03006 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | EIF3G |
case <OC:Mammalia> | |
Protein name | RecName: Full=Eukaryotic translation initiation factor 3 subunit G; Short=eIF3g; AltName: Full=Eukaryotic translation initiation factor 3 subunit 4; AltName: Full=eIF-3-delta; AltName: Full=Eukaryotic translation initiation factor 3 RNA-binding subunit; Short=eIF-3 RNA-binding subunit; AltName: Full=eIF3 p44; AltName: Full=eIF3 p42; |
else case <OC:Fungi> | |
Protein name | RecName: Full=Eukaryotic translation initiation factor 3 subunit G; Short=eIF3g; AltName: Full=Translation initiation factor eIF3 p33 subunit homolog; Short=eIF3 p33 homolog; AltName: Full=Eukaryotic translation initiation factor 3 RNA-binding subunit; Short=eIF-3 RNA-binding subunit; |
else | |
Protein name | RecName: Full=Eukaryotic translation initiation factor 3 subunit G; Short=eIF3g; AltName: Full=Eukaryotic translation initiation factor 3 subunit 4; AltName: Full=Eukaryotic translation initiation factor 3 RNA-binding subunit; Short=eIF-3 RNA-binding subunit; |
end case | |
case <OC:Vertebrata> | |
Gene name | Name=EIF3G; Synonyms=EIF3S4; |
else case <OC:Caenorhabditis> | |
Gene name | Name=eif-3.G; |
else case <OC:Drosophilidae> | |
Gene name | Name=eIF3g; Synonyms=eIF3-S4; |
else case <OC:Fungi> | |
Gene name | Name=TIF35; |
end case |
Comments
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case <OC:Mammalia> | |
FUNCTION | RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre- initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. This subunit can bind 18S rRNA. |
else | |
FUNCTION | RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. This subunit can bind 18S rRNA. |
end case | |
case <OC:Mammalia> | |
SUBUNIT | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of FRAP1 and RAPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts (via C-terminus) with AIFM1 (via N-terminus). |
else case <OC:Vertebrata> and not <OC:Mammalia> | |
SUBUNIT | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: @gn(EIF3A), @gn(EIF3B), @gn(EIF3C), @gn(EIF3D), @gn(EIF3E), @gn(EIF3F), @gn(EIF3G), @gn(EIF3H), @gn(EIF3I), @gn(EIF3J), @gn(EIF3K), @gn(EIF3L) and @gn(EIF3M). |
else case <OC:Drosophilidae> | |
SUBUNIT | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex. The eIF-3 complex interacts with pix. |
else | |
SUBUNIT | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex. |
end case | |
case <OC:Mammalia> | |
SUBCELLULAR LOCATION | Cytoplasm. Nucleus. Cytoplasm, perinuclear region. Note=Colocalizes with AIFM1 in the nucleus and perinuclear region. |
else | |
SUBCELLULAR LOCATION | Cytoplasm. |
end case | |
case <OC:Mammalia> | |
PTM | Phosphorylated. Phosphorylation is enhanced upon serum stimulation. |
end case | |
SIMILARITY | Belongs to the eIF-3 subunit G family. |
Keywords
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Cytoplasm | |
Initiation factor | |
Protein biosynthesis | |
case <OC:Mammalia> | |
Phosphoprotein | |
end case |
Gene Ontology
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GO:0003723; Molecular function:RNA binding | |
GO:0003743; Molecular function:translation initiation factor activity | |
GO:0001732; Biological process:formation of cytoplasmic translation initiation complex | |
GO:0002183; Biological process:cytoplasmic translational initiation | |
GO:0005737; Cellular component:cytoplasm | |
case <OCellular component:Mammalia> | |
GO:0005634; Cellular component:nucleus | |
end case | |
GO:0005852; Cellular component:eukaryotic translation initiation factor 3 complex | |
GO:0016282; Cellular component:eukaryotic 43S preinitiation complex | |
GO:0033290; Cellular component:eukaryotic 48S preinitiation complex |
Cross-references
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Features
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From: EIF3G_HUMAN (O75821) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
case <OC:Mammalia> | ||||||||||||
INIT_MET | 1 | 1 | /note="Removed" | M | ||||||||
MOD_RES | 41 | 41 | /note="Phosphothreonine" | T | ||||||||
MOD_RES | 42 | 42 | /note="Phosphoserine" | S | ||||||||
end case |
Additional information
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Size range | 233-352 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |