HAMAP rule MF_03012
General rule information
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| Accession | MF_03012 |
| Dates | 4-FEB-2009 (Created)
20-NOV-2019 (Last updated, Version 16) |
| Name | eIF3m |
| Scope(s) |
Eukaryota |
| Template(s) | Q7L2H7 (EIF3M_HUMAN); Q94261 (EIF3M_CAEEL); Q7JVI3 (EIF3M_DROME); Q09722 (EIF3M_SCHPO); [ Recover all ] |
| Triggered by |
HAMAP; MF_03012 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | EIF3M |
| case <OC:Caenorhabditis> | |
| Protein name | RecName: Full=COP9/Signalosome and eIF3 complex-shared subunit 1; AltName: Full=COP9 signalosome complex subunit 7; Short=Signalosome subunit 7; AltName: Full=Eukaryotic translation initiation factor 3 subunit M; Short=eIF3m; |
| else case <OC:Drosophilidae> | |
| Protein name | RecName: Full=Eukaryotic translation initiation factor 3 subunit M; Short=eIF3m; AltName: Full=Transport and Golgi organization protein 7; Short=Tango-7; |
| else | |
| Protein name | RecName: Full=Eukaryotic translation initiation factor 3 subunit M; Short=eIF3m; |
| end case | |
| case <OC:Vertebrata> | |
| Gene name | Name=EIF3M; |
| else case <OC:Caenorhabditis> | |
| Gene name | Name=cif-1; Synonyms=csn-7, eif-3.M; |
| else case <OC:Drosophilidae> | |
| Gene name | Name=eIF3m; Synonyms=Tango7; |
| end case | |
Comments
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| case <OC:Mammalia> | |
| FUNCTION | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. |
| else case <OC:Caenorhabditis> | |
| FUNCTION | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. The CSN complex plays an essential role in embryogenesis and oogenesis and is required to regulate microtubule stability in the early embryo. Mediates mei-1 targeting for degradation at the meiosis to mitosis transition via deneddylation of cul-3. |
| else | |
| FUNCTION | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. |
| end case | |
| case <OC:Mammalia> | |
| SUBUNIT | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. |
| else case <OC:Vertebrata> and not <OC:Mammalia> | |
| SUBUNIT | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: @gn(EIF3A), @gn(EIF3B), @gn(EIF3C), @gn(EIF3D), @gn(EIF3E), @gn(EIF3F), @gn(EIF3G), @gn(EIF3H), @gn(EIF3I), @gn(EIF3J), @gn(EIF3K), @gn(EIF3L) and @gn(EIF3M). |
| else case <OC:Drosophilidae> | |
| SUBUNIT | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex. The eIF-3 complex interacts with pix. |
| else case <OC:Caenorhabditis> | |
| SUBUNIT | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex. Within the eIF-3 complex, interacts directly with eif- 3.F. Component of the CSN complex, composed of csn-1, csn-2, csn-3, csn-4, csn-5, csn-6 and csn-7. Within the CSN complex, interacts directly with csn-1 and csn-4. |
| else | |
| SUBUNIT | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex. |
| end case | |
| case <OC:Drosophilidae> | |
| SUBCELLULAR LOCATION | Cytoplasm. Golgi apparatus. |
| else | |
| SUBCELLULAR LOCATION | Cytoplasm. |
| end case | |
| SIMILARITY | Belongs to the eIF-3 subunit M family. |
Keywords
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| Cytoplasm | |
| Initiation factor | |
| Protein biosynthesis | |
| case <OC:Drosophilidae> | |
| Golgi apparatus | |
| end case | |
| case <OC:Caenorhabditis> | |
| Developmental protein | |
| Differentiation | |
| Oogenesis | |
| Signalosome | |
| end case | |
| case <FTTag:acetyl> | |
| Acetylation | |
| end case | |
Gene Ontology
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| GO:0003743; Molecular function:translation initiation factor activity | |
| case <OCellular component:Caenorhabditis> | |
| GO:0000338; Biological process:protein deneddylation | |
| end case | |
| GO:0001732; Biological process:formation of cytoplasmic translation initiation complex | |
| GO:0002183; Biological process:cytoplasmic translational initiation | |
| GO:0005737; Cellular component:cytoplasm | |
| case <OCellular component:Drosophilidae> | |
| GO:0005794; Cellular component:Golgi apparatus | |
| end case | |
| GO:0071541; Cellular component:eukaryotic translation initiation factor 3 complex, eIF3m | |
| case <OCellular component:Caenorhabditis> | |
| GO:0008180; Cellular component:COP9 signalosome | |
| end case | |
| GO:0016282; Cellular component:eukaryotic 43S preinitiation complex | |
| GO:0033290; Cellular component:eukaryotic 48S preinitiation complex | |
Cross-references
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Features
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| From: EIF3M_HUMAN (Q7L2H7) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| case <OC:Mammalia> | ||||||||||||
| INIT_MET | 1 | 1 | /note="Removed" | M | ||||||||
| MOD_RES | 2 | 2 | /note="N-acetylserine" | acetyl | S | |||||||
| end case | ||||||||||||
Additional information
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| Size range | 373-555 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |