HAMAP rule MF_03018
General rule information
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Accession | MF_03018 |
Dates | 12-FEB-2009 (Created)
20-NOV-2019 (Last updated, Version 14) |
Name | Kynurenine_monooxygenase_euk |
Scope(s) |
Eukaryota |
Template(s) | O15229 (KMO_HUMAN); Q91WN4 (KMO_MOUSE); O88867 (KMO_RAT); Q86PM2 (KMO_AEDAE); P38169 (KMO_YEAST); [ Recover all ] |
Triggered by |
case c? <OC:Eukaryota>
HAMAP; MF_01971 (Get profile general information and statistics) end case
|
Propagated annotation
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Identifier, protein and gene names
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Identifier | KMO |
case <OC:Fungi> | |
Protein name | RecName: Full=Kynurenine 3-monooxygenase; EC=1.14.13.9; AltName: Full=Biosynthesis of nicotinic acid protein 4; AltName: Full=Kynurenine 3-hydroxylase; |
else | |
Protein name | RecName: Full=Kynurenine 3-monooxygenase; EC=1.14.13.9; AltName: Full=Kynurenine 3-hydroxylase; |
end case | |
case <OC:Dictyostelium> | |
Gene name | Name=kmo; |
else case <OC:Drosophilidae> | |
Gene name | Name=cn; |
else case <OC:Fungi> | |
Gene name | Name=BNA4; |
else case <OC:Eukaryota> and not <OC:Arthropoda> and not <OC:Nematoda> | |
Gene name | Name=KMO; |
end case |
Comments
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case <OC:Mammalia> | |
FUNCTION | Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract. |
else | |
FUNCTION | Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid. |
end case | |
CATALYTIC ACTIVITY | Reaction=H(+) + L-kynurenine + NADPH + O2 = 3-hydroxy-L-kynurenine + H2O + NADP(+); Xref=Rhea:RHEA:20545, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57783, ChEBI:CHEBI:57959, ChEBI:CHEBI:58125, ChEBI:CHEBI:58349; EC=1.14.13.9; |
COFACTOR | Name=FAD; Xref=ChEBI:CHEBI:57692; |
PATHWAY | Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 1/3. |
case <OC:Vertebrata> | |
SUBCELLULAR LOCATION | Mitochondrion outer membrane; Multi-pass membrane protein. |
else case <OC:Arthropoda> or <OC:Nematoda> | |
SUBCELLULAR LOCATION | Mitochondrion. Membrane; Multi-pass membrane protein. |
else case <OC:Fungi> | |
SUBCELLULAR LOCATION | Mitochondrion outer membrane. |
else | |
SUBCELLULAR LOCATION | Mitochondrion. |
end case | |
SIMILARITY | Belongs to the aromatic-ring hydroxylase family. KMO subfamily. |
Keywords
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FAD | |
Flavoprotein | |
Mitochondrion | |
case <OC:Vertebrata> or <OC:Arthropoda> or <OC:Nematoda> or <OC:Fungi> | |
Membrane | |
end case | |
case <OC:Vertebrata> or <OC:Fungi> | |
Mitochondrion outer membrane | |
end case | |
Monooxygenase | |
NADP | |
Oxidoreductase | |
Pyridine nucleotide biosynthesis | |
case <FTTag:transmembrane> | |
Transmembrane | |
Transmembrane helix | |
end case |
Gene Ontology
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GO:0004502; Molecular function:kynurenine 3-monooxygenase activity | |
GO:0050660; Molecular function:flavin adenine dinucleotide binding | |
GO:0006569; Biological process:tryptophan catabolic process | |
GO:0019805; Biological process:quinolinate biosynthetic process | |
GO:0034354; Biological process:'de novo' NAD biosynthetic process from tryptophan | |
GO:0043420; Biological process:anthranilate metabolic process | |
case <OCellular component:Vertebrata> or <OC:Arthropoda> or <OC:Nematoda> or <OC:Fungi> | |
GO:0031966; Cellular component:mitochondrial membrane | |
else; https://www.ebi.ac.uk/QuickGO/term/else | |
GO:0005739; Cellular component:mitochondrion | |
end case |
Cross-references
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Features
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From: KMO_HUMAN (O15229) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
case <OC:Vertebrata> | ||||||||||||
TRANSMEM | 385 | 404 | /note="Helical" | transmembrane | ||||||||
TRANSMEM | 425 | 445 | /note="Helical" | transmembrane | ||||||||
end case | ||||||||||||
From: KMO_DROME (A1Z746) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
case <OC:Arthropoda> | ||||||||||||
TRANSMEM | 405 | 427 | /note="Helical" | transmembrane | ||||||||
TRANSMEM | 440 | 462 | /note="Helical" | transmembrane | ||||||||
end case | ||||||||||||
From: KMO_CAEBR (A8Y432) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
case <OC:Nematoda> | ||||||||||||
TRANSMEM | 395 | 415 | /note="Helical" | transmembrane | ||||||||
TRANSMEM | 432 | 452 | /note="Helical" | transmembrane | ||||||||
end case |
Additional information
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Size range | 427-600 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |