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HAMAP rule MF_03018

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General rule information [?]

Accession MF_03018
Dates 12-FEB-2009 (Created)
20-NOV-2019 (Last updated, Version 14)
Name Kynurenine_monooxygenase_euk
Scope(s) Eukaryota
Template(s) O15229 (KMO_HUMAN); Q91WN4 (KMO_MOUSE); O88867 (KMO_RAT); Q86PM2 (KMO_AEDAE); P38169 (KMO_YEAST); [ Recover all ]
Triggered by
case c? <OC:Eukaryota>
HAMAP; MF_01971 (Get profile general information and statistics)
end case

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier KMO
case <OC:Fungi>
Protein name RecName: Full=Kynurenine 3-monooxygenase;
                 EC=1.14.13.9;
AltName: Full=Biosynthesis of nicotinic acid protein 4;
AltName: Full=Kynurenine 3-hydroxylase;
else
Protein name RecName: Full=Kynurenine 3-monooxygenase;
                 EC=1.14.13.9;
AltName: Full=Kynurenine 3-hydroxylase;
end case
case <OC:Dictyostelium>
Gene name Name=kmo;
else case <OC:Drosophilidae>
Gene name Name=cn;
else case <OC:Fungi>
Gene name Name=BNA4;
else case <OC:Eukaryota> and not <OC:Arthropoda> and not <OC:Nematoda>
Gene name Name=KMO;
end case

Comments [?]

case <OC:Mammalia>
FUNCTIONCatalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract.
else
FUNCTIONCatalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.
end case
CATALYTIC ACTIVITY Reaction=H(+) + L-kynurenine + NADPH + O2 = 3-hydroxy-L-kynurenine + H2O + NADP(+); Xref=Rhea:RHEA:20545, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57783, ChEBI:CHEBI:57959, ChEBI:CHEBI:58125, ChEBI:CHEBI:58349; EC=1.14.13.9;
COFACTOR Name=FAD; Xref=ChEBI:CHEBI:57692;
PATHWAYCofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 1/3.
case <OC:Vertebrata>
SUBCELLULAR LOCATIONMitochondrion outer membrane; Multi-pass membrane protein.
else case <OC:Arthropoda> or <OC:Nematoda>
SUBCELLULAR LOCATIONMitochondrion. Membrane; Multi-pass membrane protein.
else case <OC:Fungi>
SUBCELLULAR LOCATIONMitochondrion outer membrane.
else
SUBCELLULAR LOCATIONMitochondrion.
end case
SIMILARITYBelongs to the aromatic-ring hydroxylase family. KMO subfamily.

Keywords [?]

FAD
Flavoprotein
Mitochondrion
case <OC:Vertebrata> or <OC:Arthropoda> or <OC:Nematoda> or <OC:Fungi>
Membrane
end case
case <OC:Vertebrata> or <OC:Fungi>
Mitochondrion outer membrane
end case
Monooxygenase
NADP
Oxidoreductase
Pyridine nucleotide biosynthesis
case <FTTag:transmembrane>
Transmembrane
Transmembrane helix
end case

Gene Ontology [?]

GO:0004502; Molecular function:kynurenine 3-monooxygenase activity
GO:0050660; Molecular function:flavin adenine dinucleotide binding
GO:0006569; Biological process:tryptophan catabolic process
GO:0019805; Biological process:quinolinate biosynthetic process
GO:0034354; Biological process:'de novo' NAD biosynthetic process from tryptophan
GO:0043420; Biological process:anthranilate metabolic process
case <OCellular component:Vertebrata> or <OC:Arthropoda> or <OC:Nematoda> or <OC:Fungi>
GO:0031966; Cellular component:mitochondrial membrane
else; https://www.ebi.ac.uk/QuickGO/term/else
GO:0005739; Cellular component:mitochondrion
end case

Cross-references [?]

Pfam PF01266; DAO; 1;
PRINTS PR00420; RNGMNOXGNASE; 1;

Features [?]

From: KMO_HUMAN (O15229)
Key From To Description Tag Condition FTGroup
case <OC:Vertebrata>
TRANSMEM 385 404 /note="Helical" transmembrane
TRANSMEM 425 445 /note="Helical" transmembrane
end case
From: KMO_DROME (A1Z746)
Key From To Description Tag Condition FTGroup
case <OC:Arthropoda>
TRANSMEM 405 427 /note="Helical" transmembrane
TRANSMEM 440 462 /note="Helical" transmembrane
end case
From: KMO_CAEBR (A8Y432)
Key From To Description Tag Condition FTGroup
case <OC:Nematoda>
TRANSMEM 395 415 /note="Helical" transmembrane
TRANSMEM 432 452 /note="Helical" transmembrane
end case

Additional information [?]

Size range 427-600 amino acids
Related rules None
Fusion Nter: None Cter: None



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