HAMAP rule MF_03028
General rule information
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| PURL | https://purl.expasy.org/hamap/rule/MF_03028 |
| Accession | MF_03028 |
| Dates | 12-MAR-2009 (Created)
20-NOV-2019 (Last updated, Version 9) |
| Name | Pescadillo |
| Scope(s) |
Eukaryota |
| Template(s) | O00541 (PESC_HUMAN); Q9EQ61 (PESC_MOUSE); P79741 (PESC_DANRE); Q95Y89 (PESC_CAEEL); Q9VL96 (PESC_DROME); P53261 (PESC_YEAST); [ Recover all ] |
| Triggered by |
HAMAP; MF_03028 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | PESC |
| case <OC:Caenorhabditis> | |
| Protein name | RecName: Full=Pescadillo homolog; AltName: Full=Lipid depleted protein 7; |
| else case <OC:Fungi> | |
| Protein name | RecName: Full=Pescadillo homolog; AltName: Full=Nucleolar protein 7 homolog; |
| else | |
| Protein name | RecName: Full=Pescadillo homolog; |
| end case | |
| case <OC:Vertebrata> | |
| Gene name | Name=PES1; |
| else case <OC:Caenorhabditis> | |
| Gene name | Name=lpd-7; |
| else case <OC:Fungi> | |
| Gene name | Name=NOP7; |
| end case | |
Comments
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| case <OC:Vertebrata> | |
| FUNCTION | Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. |
| else case <OC:Fungi> | |
| FUNCTION | Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome. |
| else | |
| FUNCTION | Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit. |
| end case | |
| case <OC:Mammalia> | |
| SUBUNIT | Component of the PeBoW complex, composed of BOP1, PES1 and WDR12. Within the PeBoW complex BOP1 interacts directly with PES1 and WDR12. The PeBoW complex also associates with the 66S pre-ribosome. Interacts with IRS1 and UBTF. May interact with MAP1B. |
| else case <OC:Vertebrata> | |
| SUBUNIT | Component of the PeBoW complex, composed of @gn(BOP1), @gn(PES1) and @gn(WDR12). Within the PeBoW complex @gn(BOP1) interacts directly with @gn(PES1) and @gn(WDR12). The PeBoW complex also associates with the 66S pre-ribosome. |
| else case <OC:Fungi> | |
| SUBUNIT | Component of the NOP7 complex, composed of @gn(ERB1), @gn(NOP7) and @gn(YTM1). Within the NOP7 complex @gn(ERB1) appears to interact directly with @gn(NOP7) and @gn(YTM1). The NOP7 complex also associates with the 66S pre-ribosome. |
| end case | |
| case <OC:Mammalia> | |
| SUBCELLULAR LOCATION | Nucleus, nucleolus. Nucleus, nucleoplasm. Chromosome. Note=Appears to localize to the periphery of metaphase chromosomes during mitosis and to the prenucleolar bodies that form in mitotic cells prior to the actual nucleoli. |
| else | |
| SUBCELLULAR LOCATION | Nucleus, nucleolus. Nucleus, nucleoplasm. |
| end case | |
| case <OC:Mammalia> | |
| PTM | Sumoylated. |
| end case | |
| SIMILARITY | Belongs to the pescadillo family. |
Keywords
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| Nucleus | |
| Ribosome biogenesis | |
| rRNA processing | |
| case <OC:Mammalia> | |
| Chromosome | |
| Ubl conjugation | |
| end case | |
Gene Ontology
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| GO:0043021; Molecular function:ribonucleoprotein complex binding |
| GO:0000463; Biological process:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) |
| GO:0000466; Biological process:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) |
| GO:0042273; Biological process:ribosomal large subunit biogenesis |
| GO:0005634; Cellular component:nucleus |
| GO:0005730; Cellular component:nucleolus |
| GO:0030687; Cellular component:preribosome, large subunit precursor |
Cross-references
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| PROSITE | PS50172; BRCT; 1; |
| Pfam | PF00533; BRCT; 1; |
| Pfam | PF06732; Pescadillo_N; 1; |
| PROSITE | PS50312; ASP_RICH; 0-unlimited; |
| PROSITE | PS50313; GLU_RICH; 0-unlimited; |
| PROSITE | PS50318; LYS_RICH; 0-unlimited; |
| PROSITE | PS50323; ARG_RICH; 0-unlimited; |
| General | Coiled_coil; -; 0-unlimited; |
Features
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Additional information
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| Size range | 451-725 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |