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HAMAP rule MF_03028

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General rule information [?]

Accession MF_03028
Dates 12-MAR-2009 (Created)
20-NOV-2019 (Last updated, Version 9)
Name Pescadillo
Scope(s) Eukaryota
Template(s) O00541 (PESC_HUMAN); Q9EQ61 (PESC_MOUSE); P79741 (PESC_DANRE); Q95Y89 (PESC_CAEEL); Q9VL96 (PESC_DROME); P53261 (PESC_YEAST); [ Recover all ]
Triggered by HAMAP; MF_03028 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier PESC
case <OC:Caenorhabditis>
Protein name RecName: Full=Pescadillo homolog;
AltName: Full=Lipid depleted protein 7;
else case <OC:Fungi>
Protein name RecName: Full=Pescadillo homolog;
AltName: Full=Nucleolar protein 7 homolog;
else
Protein name RecName: Full=Pescadillo homolog;
end case
case <OC:Vertebrata>
Gene name Name=PES1;
else case <OC:Caenorhabditis>
Gene name Name=lpd-7;
else case <OC:Fungi>
Gene name Name=NOP7;
end case

Comments [?]

case <OC:Vertebrata>
FUNCTIONComponent of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
else case <OC:Fungi>
FUNCTIONComponent of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
else
FUNCTIONRequired for maturation of ribosomal RNAs and formation of the large ribosomal subunit.
end case
case <OC:Mammalia>
SUBUNITComponent of the PeBoW complex, composed of BOP1, PES1 and WDR12. Within the PeBoW complex BOP1 interacts directly with PES1 and WDR12. The PeBoW complex also associates with the 66S pre-ribosome. Interacts with IRS1 and UBTF. May interact with MAP1B.
else case <OC:Vertebrata>
SUBUNITComponent of the PeBoW complex, composed of @gn(BOP1), @gn(PES1) and @gn(WDR12). Within the PeBoW complex @gn(BOP1) interacts directly with @gn(PES1) and @gn(WDR12). The PeBoW complex also associates with the 66S pre-ribosome.
else case <OC:Fungi>
SUBUNITComponent of the NOP7 complex, composed of @gn(ERB1), @gn(NOP7) and @gn(YTM1). Within the NOP7 complex @gn(ERB1) appears to interact directly with @gn(NOP7) and @gn(YTM1). The NOP7 complex also associates with the 66S pre-ribosome.
end case
case <OC:Mammalia>
SUBCELLULAR LOCATIONNucleus, nucleolus. Nucleus, nucleoplasm. Chromosome. Note=Appears to localize to the periphery of metaphase chromosomes during mitosis and to the prenucleolar bodies that form in mitotic cells prior to the actual nucleoli.
else
SUBCELLULAR LOCATIONNucleus, nucleolus. Nucleus, nucleoplasm.
end case
case <OC:Mammalia>
PTMSumoylated.
end case
SIMILARITYBelongs to the pescadillo family.

Keywords [?]


Gene Ontology [?]

GO:0043021; Molecular function:ribonucleoprotein complex binding
GO:0000463; Biological process:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000466; Biological process:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0042273; Biological process:ribosomal large subunit biogenesis
GO:0005634; Cellular component:nucleus
GO:0005730; Cellular component:nucleolus
GO:0030687; Cellular component:preribosome, large subunit precursor

Cross-references [?]

PROSITE PS50172; BRCT; 1;
Pfam PF00533; BRCT; 1;
Pfam PF06732; Pescadillo_N; 1;
PROSITE PS50312; ASP_RICH; 0-unlimited;
PROSITE PS50313; GLU_RICH; 0-unlimited;
PROSITE PS50318; LYS_RICH; 0-unlimited;
PROSITE PS50323; ARG_RICH; 0-unlimited;
General Coiled_coil; -; 0-unlimited;

Features [?]


Additional information [?]

Size range 451-725 amino acids
Related rules None
Fusion Nter: None Cter: None



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