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HAMAP rule MF_03029

General rule information [?]

Accession	MF_03029
Dates	12-MAR-2009 (Created) 20-NOV-2019 (Last updated, Version 9)
Name	WDR12
Scope(s)	Eukaryota
Template(s)	Q9GZL7 (WDR12_HUMAN); Q12024 (YTM1_YEAST); [ Recover all ]
Triggered by	HAMAP; MF_03029 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

case <OC:Fungi>
Identifier	YTM1
else
Identifier	WDR12
end case
case <OC:Vertebrata>
Protein name	RecName: Full=Ribosome biogenesis protein @gn(WDR12); AltName: Full=WD repeat-containing protein 12;
else case <OC:Fungi>
Protein name	RecName: Full=Ribosome biogenesis protein @gn(YTM1);
else
Protein name	RecName: Full=Ribosome biogenesis protein WDR12 homolog;
end case
case <OC:Vertebrata>
Gene name	Name=WDR12;
else case <OC:Caenorhabditis>
Gene name	Name=wdr-12;
else case <OC:Fungi>
Gene name	Name=YTM1;
end case

Comments [?]

case <OC:Vertebrata>
FUNCTION	Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
else case <OC:Fungi>
FUNCTION	Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
else
FUNCTION	Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit.
end case
case <OC:Vertebrata>
SUBUNIT	Component of the PeBoW complex, composed of @gn(BOP1), @gn(PES1) and @gn(WDR12). Within the PeBoW complex @gn(BOP1) interacts directly with @gn(PES1) and @gn(WDR12). The PeBoW complex also associates with the 66S pre-ribosome.
else case <OC:Fungi>
SUBUNIT	Component of the NOP7 complex, composed of @gn(ERB1), @gn(NOP7) and @gn(YTM1). Within the NOP7 complex @gn(ERB1) appears to interact directly with @gn(NOP7) and @gn(YTM1). The NOP7 complex also associates with the 66S pre-ribosome.
end case
SUBCELLULAR LOCATION	Nucleus, nucleolus. Nucleus, nucleoplasm.
SIMILARITY	Belongs to the WD repeat WDR12/YTM1 family.

Keywords [?]

Gene Ontology [?]

GO:0043021; Molecular function:ribonucleoprotein complex binding

GO:0000463; Biological process:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

GO:0000466; Biological process:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

GO:0042273; Biological process:ribosomal large subunit biogenesis

GO:0005634; Cellular component:nucleus

GO:0005730; Cellular component:nucleolus

GO:0030687; Cellular component:preribosome, large subunit precursor

Cross-references [?]

Features [?]

Additional information [?]