HAMAP rule MF_03030
General rule information
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| Accession | MF_03030 |
| Dates | 17-JAN-2013 (Created)
20-NOV-2019 (Last updated, Version 9) |
| Name | MGME1 |
| Scope(s) |
Eukaryota Metazoa |
| Template(s) | Q9BQP7 (MGME1_HUMAN); [ Recover all ] |
| Triggered by |
HAMAP; MF_03030 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | MGME1 |
| Protein name | RecName: Full=Mitochondrial genome maintenance exonuclease 1; EC=3.1.-.-; |
| case <OC:Vertebrata> | |
| Gene name | Name=MGME1; |
| end case | |
Comments
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| case <OC:Mammalia> | |
| FUNCTION | Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity but is also capable of endoduclease activity on linear substrates. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair, possibly via the processing of displaced DNA containing Okazaki fragments during RNA- primed DNA synthesis on the lagging strand or via processing of DNA flaps during long-patch base excision repair. |
| else case <OC:Vertebrata> | |
| FUNCTION | Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair. |
| else | |
| FUNCTION | Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. |
| end case | |
| SUBCELLULAR LOCATION | Mitochondrion. |
| case not <AnyFeature:TransitM> | |
| MISCELLANEOUS | This protein may be expected to contain an N-terminal transit peptide but none has been predicted. |
| end case | |
| SIMILARITY | Belongs to the MGME1 family. |
Keywords
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Gene Ontology
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| GO:0005739; Cellular component:mitochondrion |
| GO:0000002; Biological process:mitochondrial genome maintenance |
| GO:0043504; Biological process:mitochondrial DNA repair |
| GO:0008297; Molecular function:single-stranded DNA exodeoxyribonuclease activity |
Cross-references
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| General | TransitM; -; 0-1; |
Features
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| From: MGME1_HUMAN (Q9BQP7) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 238 | 238 | D | |||||||||
| ACT_SITE | 251 | 251 | [DE] | |||||||||
| ACT_SITE | 253 | 253 | K | |||||||||
Additional information
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| Size range | 182-455 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |