HAMAP rule MF_03032

General rule information [?]

Accession	MF_03032
Dates	14-APR-2009 (Created) 15-FEB-2022 (Last updated, Version 11)
Name	AGO3
Scope(s)	Eukaryota Vertebrata
Template(s)	Q9H9G7 (AGO3_HUMAN); Q8CJF9 (AGO3_MOUSE); [ Recover all ]
Triggered by	HAMAP; MF_03032 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	AGO3
Protein name	RecName: Full=Protein argonaute-3; Short=Argonaute3; AltName: Full=Eukaryotic translation initiation factor 2C 3; Short=eIF-2C 3; Short=eIF2C 3;
Gene name	Name=EIF2C3; Synonyms=AGO3;

Comments [?]

FUNCTION	Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.
case <OC:Mammalia>
SUBUNIT	Interacts with EIF4B, IMP8, PRMT5 and TNRC6B. Interacts with APOBEC3F, APOBEC3G and APOBEC3H.
end case
SUBCELLULAR LOCATION	Cytoplasm, P-body.
SIMILARITY	Belongs to the argonaute family. Ago subfamily.

Keywords [?]

Gene Ontology [?]

GO:0035198; Molecular function:miRNA binding

GO:0035278; Biological process:miRNA-mediated gene silencing by inhibition of translation

GO:0016442; Cellular component:RISC complex

Cross-references [?]

Features [?]

Additional information [?]